Immunity inducer for saccharide antigens

An artificial glycolipid having chemical formula (2) or a salt thereof:

• R—Z—Y—CH(NH—CO—(CH2)n1—CH3)—(CH2)n2—CH3 chemical formula (2)
• wherein, in the chemical formula (2), R represents a linear chain or branched oligosaccharide constituted with 2 to 30 of one type or plural types of monosaccharides, Z represents a single bond, O, S or NH, a linker bound to thiomethyl, or an aminomethylated sugar alcohol, Y represents —(CH2)m—, n1 represents an integer from 20 to 40, n2 represents an integer from 1 to 27, and m represents an integer from 1 to 30, and
• wherein R is an oligosaccharide antigen selected from the group consisting of
• an oligosaccharide antigen included in a mammal-derived glycoprotein N-linked sugar chain selected from the group consisting of Siaα2,6Galβ1,4GlcNAc, Siaα2,3Galβ1,4GlcNAc, Galβ1,4GlcNAc, Galβ1,3GlcNAc, Siaα2,3Galβ1,4(Fucα1,3)GlcNAc, Galβ1,4 (Fucα1,3)GlcNAc, Siaα2,3Galβ1,3(Fucα1,4)GlcNAc, Siaα2,3Galβ1,3GlcNAc, Galβ1,3(Fucα1,4)GlcNAc, Siaα2,3Galβ1,3 (Siaα2,6)GlcNAc, Siaα2,3Galβ1,3 (Fucα1,4)(Siaα2,6)GlcNAc, Fucα1,2Galβ1,3(Fucα1,4)GlcNAc, Fucα1,2Galβ1,4GlcNAc, Fucα1,2Galβ1,4(Fucα1,3)GlcNAc, Fucα1,6GlcNAc, GlcNAcβ1,4 (Fucα1,6)GlcNAc, Manβ1,4GlcNAcβ1,4(Fucα1,6)GlcNAc, Manα1,6(Manα1,3)Manβ1,4GlcNAcβ1,4(Fucα1,6)GlcNAc, Manα1,6 (GlcNAcβ1,4) (Manα1,3)Manβ1,4GlcNAcβ1,4GlcNAc, Manα1,6 (GlcNAcβ1,4) (Manα1,3)Manβ1,4GlcNAcβ1,4(Fucα1,6)GlcNAc, GlcNAcβ1,4GlcNAc, Manβ1,4GlcNAcβ1,4 GlcNAc, GlcNAcβ1,2Man, GlcNAcβ1,4Man, GlcNAcβ1,6Man, Galβ1,3GlcNAcβ1,2Man, Galβ1,3GlcNAcβ1,4Man, Galβ1,3GlcNAcβ1,6Man, Galβ1,4GlcNAcβ1,2Man, Galβ1,4GlcNAcβ1,4Man, Galβ1,4GlcNAcβ1,6Man, Siaα2,3Galβ1,4GlcNAcβ1,2Man, Siaα2,3Galβ1,4GlcNAcβ1,4Man, Siaα2,3Galβ1,4GlcNAcβ1,6Man, Siaα2,3Galβ1,3GlcNAcβ1,2Man, Siaα2,3Galβ1,3GlcNAcβ1,4Man, Siaα2,3Galβ1,3GlcNAcβ1,6Man, Siaα2,6Galβ1,4GlcNAcβ1,2Man, Siaα2,6Galβ1,4GlcNAcβ1,4Man, Siaα2,6Galβ1,4GlcNAcβ1,6Man, GalNAcβ1,4GlcNAc, GalNAcβ1,4GlcNAcβ1,2Man, GalNAc(4SO4)β1,4GlcNAc, GalNAc(4SO4)β1,4GlcNAcβ1,2Man, GalNAc(4SO4)β1,4GlcNAcβ1,4Man, GalNAc(4SO4)β1,4GlcNAcβ1,6Man, GlcAβ1,3Galβ1,4GlcNAc, GlcA(3SO4)β1,3Galβ1,4GlcNAc, Siaα2,3Galβ1,4(Fucα1,3)GlcNAc(6SO4), Siaα2,3Galβ1,4GlcNAc(6SO4), Galβ1,4GlcNAc(6SO4), Galβ1,4(Fucα1,3) GlcNAc(6SO4), Siaα2,3Gal(6SO4)β1,4(Fucα1,3)GlcNAc, Siaα2,3Gal(6SO4)β1,4GlcNAc, Gal(6SO4)β1,4GlcNAc, Gal(6SO4)β1,4GlcNAc(6SO4), Galβ1,4GlcNAcβ1,3Gal, GlcNAcβ1,3Galβ1,4GlcNAc, Galβ1,4GlcNAc(6SO4)β1,3Gal, GlcNAc(6SO4)β1,3Galβ1,4GlcNAc, Gal(6SO4)β1,4GlcNAc(6SO4)β1,3Gal, GlcNAc(6SO4)β1,3Gal(6SO4)β1,4GlcNAc, Siaα2,3Galβ1,4GlcNAcβ1,3Galβ1,4(Fucα1,3)GlcNAc, Fucα1,2Galβ1,3GlcNAc, Galα1,3(Fucα1,2)Galβ1,3GlcNAc, Galα1,3(Fucα1,2)Galβ1,4GlcNAc, GalNAcα1,3(Fucα1,2)Galβ1,3GlcNAc, GalNAcα1,3(Fucα1,2)Galβ1,4GlcNAc, Fucα1,2Galβ1,4(Fucα1,3)GlcNAcβ1,3Gal, Gal(3SO4)β1,4GlcNAc, Gal(3SO4)β1,4(Fucα1,3)GlcNAc, Gal(3SO4)β1,3GlcNAc, Gal(3SO4)β1,3(Fucα1,4)GlcNAc, Gal(3SO4)β1,4GlcNAc(6SO4), Gal(3SO4)β1,4(Fucα1,3)GlcNAc(6SO4), Siaα2,8Siaα2,8Sia, Siaα2,6GalNAcβ1,4GlcNAc, Siaα2,3Galβ1,4(Fucα1,3)GlcNAcβ1,3Galβ1,4(Fucα1,3)GlcNAc, Galβ1,4GlcNAcβ1,3(Galβ1,4GlcNAcβ1,6)Gal, and Siaα2,3Galβ1,4GlcNAcβ1,3(Siaα2,3Galβ1,4GlcNAcβ1,6)Gal,
• an oligosaccharide antigen included in a mammal-derived glycoprotein O-linked sugar chain selected from the group consisting of Siaα2,3Galβ1,3GalNAc, Galβ1,3GalNAc, Siaα2,3Galβ1,3(GlcNAcβ1,6)GalNAc, GalNAcα1,3GalNAc, GlcNAcβ1,3(Siaα2,6)GalNAc, GalNAcα1,6GalNAc, GlcNAcβ1,6GalNAc, Fucα1,2GalNAc, Galβ1,3(GlcNAcβ1,6)GalNAc, Siaα2,6GalNAc, Siaα2,6(GlcNAcβ1,6)GalNAc, Siaα2,3Galβ1,3(Siaα2,6)GalNAc, Galβ1,4GalNAc, Siaα2,3Galβ1,4GalNAc, GlcNAcα1,4Gal, GlcNAcα1,4Galβ1,4GlcNAc, GlcNAcα1,4Galβ1,4GalNAc, GlcNAcα1,4Galβ1,4(GlcNAcα1,4Galβ1,4GlcNAcβ1,6)GalNAc, Siaα2,3Galβ1,4(Fucα1,3)GlcNAc(6SO4)β1,6GalNAc, Gal(3SO4)β1,4GlcNAcβ1,6(Siaα2,3Galβ1,3)GalNAc, Siaα2,3Galβ1,4(Fucα1,3)GlcNAc(6SO4)β1,3Galβ1,3GalNAc, Siaα2,3Galβ1,4(Fucα1,3)GlcNAc(6SO4)β1,3Galβ1,3(Siaα2,3Galβ1,4(Fucα1,3)GlcNAc(6SO4)β1,6)GalNAc, Siaα2,3Gal(6SO4) β1,4GlcNAcβ1,3Galβ1,3GalNAc, Gal(3SO4)β1,3GalNAc(6SO4), Siaα2,3Galβ1,3GalNAc(6SO4), Gal(3SO4)β1,3(Siaα2,6)GalNAc, and Gal(3SO4)β1,3GalNAc, and
• an oligosaccharide antigen included in a mammal-derived glycosaminoglycan type sugar chain selected from the group consisting of Galβ1,4Xyl, Galβ1,3Galβ1,4Xyl, GlcAβ1,3Galβ1,3Galβ1,4Xyl, GalNAcβ1,4IdoAα1,3Galβ1,3Galβ1,4Xyl, GalNAcβ1,4GlcAβ1,3Galβ1,3Galβ1,4Xyl, GlcNAcα1,4GlcAβ1,3Galβ1,3Galβ1,4Xyl, GlcAβ1,3GalNAcβ1,4GlcA, GalNAcβ1,4GlcAβ1,3GalNAc, GlcAβ1,3GalNAc(4SO4)β1,4GlcA, GalNAc(4SO4)β1,4 GlcAβ1,3GalNAc, GlcAβ1,3GalNAc(6SO4)β1,4GlcA, GalNAc(6SO4)β1,4 GlcAβ1,3GalNAc, GlcA(2SO4)β1,3(6SO4)GalNAcβ1,4GlcA, GalNAc(6SO4)β1,4GlcA(2SO4)β1,3GalNAc, GlcAβ1,3GalNAc(4,6SO4)β1,4GlcA, GalNAc(4,6SO4)β1,4GlcAβ1,3GalNAc, GalNAc(4,6SO4)β1,4GlcA(2SO4)β1,3GalNAc(6SO4), IdoAα1,3GalNAcβ1,4IdoA, GalNAcβ1,4IdoAα1,3GalNAc, IdoAα1,3GalNAc(4SO4)β1,4IdoA, GalNAc(4SO4)β1,4IdoAα1,3GalNAc, GlcAβ1,4GlcNAcα1,4GlcA, GlcNAcα1,4GlcAβ1,4GlcNAc, GlcA(2SO4)β1,4GlcNAcα1,4GlcA, GlcNAcα1,4GlcA(2SO4)β1,4GlcNAc, IdoA(2SO4)α1,4GlcNAcα1,4GlcA, GlcNAcα1,4IdoA(2SO4)α1,4GlcNAc, GlcA(2SO4)β1,4GlcNSO3α1,4GlcA, GlcNSO3α1,4GlcA(2SO4)β1,4GlcNAc, IdoA(2SO4)α1,4GlcNSO3Hα1,4GlcA, GlcNSO3α1,4IdoA(2SO4)α1,4GlcNAc, GlcAβ1,4GlcNα1,4GlcA, GlcAβ1,4GlcNSO3α1,4GlcA, GlcNSO3α1,4GlcAβ1,4GlcNAc, IdoAα1,4GlcNSO3α1,4GlcA, GlcNSO3α1,4IdoAα1,4GlcNAc, GlcAβ1,4GlcNSO3(6SO4)α1,4GlcA, GlcNSO3(6SO4)α1,4GlcAβ1,4GlcNAc, IdoAα1,4GlcNSO3(6SO4)α1,4GlcA, GlcNSO3(6SO4)α1,4IdoAα1,4GlcNAc, IdoA(2SO4)α1,4GlcNSO3(6SO4)α1,4GlcA, GlcNSO3(6SO4)α1,4IdoA(2SO4)α1,4GlcNAc, IdoAα1,4 GlcNSO3α1,4IdoA, GlcAβ1,3GlcNAcβ1,4GlcA, GlcNAcβ1,4GlcAβ1,3GlcNAc, IdoAα1,4GlcNSO3, IdoAα1,4GlcNSO3(6SO4), IdoA(2SO4)α1,4GlcNSO3, IdoA(2SO4)α1,4GlcNSO3(6SO4), IdoA(2SO4)α1,4GlcNSO3(3SO4), GlcAβ1,4GlcNSO3, GlcAβ1,4GlcNSO3(6SO4), GlcA(2SO4)β1,4GlcNAc, GlcA(2SO4)β1,4GlcNSO4(3SO4), GlcAβ1,4GlcNSO3(3,6SO4), and GlcAβ1,4GlcNSO3(3SO4).

An immunity inducing method antigen-specific to a target oligosaccharide antigen R in a mammal, comprising:

• administering an immunity inducer comprising an artificial glycolipid or a salt thereof as an effective component to the mammal, wherein the artificial glycolipid has the chemical formula (2) and includes the target oligosaccharide antigen R:
• R—Z—Y—CH(NH—CO—(CH2)n1—CH3)—(CH2)n2—CH3 chemical formula (2)
• wherein, in the chemical formula (2), R represents a linear chain or branched oligosaccharide constituted with 2 to 30 of one type or plural types of monosaccharides, Z represents a single bond, O, S or NH, a linker bound to thiomethyl, or an aminomethylated sugar alcohol, Y represents —(CH2)m—, n1 represents an integer from 2 to 40, n2 represents an integer from 1 to 27, and m represents an integer from 1 to 30, and
• wherein the target oligosaccharide antigen R is selected from the group consisting of an oligosaccharide antigen included in a mammal-derived glycoprotein N-linked sugar chain, an oligosaccharide antigen included in a mammal-derived glycoprotein O-linked sugar chain, and an oligosaccharide antigen included in a mammal-derived glycosaminoglycan type sugar chain.