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US 10,307,465 B2Granted
Pharmaceutical compositions and methods
AssigneeTyme, Inc.
InventorSteven Hoffman
Life of this patent
Estimating the term…
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AssigneeTyme, Inc.
InventorSteven Hoffman
Estimating the term…
Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof; a p450 3A4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof. Also provided are methods of reducing cell proliferation in a subject comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3A4 promoter, and a leucine aminopeptidase inhibitor to the subject in need thereof.
A method of making cancer cells more accessible to oxidative stress, comprising contacting said cancer cells with an effective amount of a tyrosine hydroxylase inhibitor and assessing oxidative stress in said cancer cells.
A method of treating cancer in a subject comprising administering to the subject an amount of α-methyl-DL-tyrosine that is effective to make cancer cells in said subject more accessible to oxidative stress.
Dependencies are inferred from the claim text.