Phytoestrogen product of red clover and pharmaceutical uses thereof

A method of modulating one or more climacteric symptoms in a subject, comprising the step of administering to the subject in need thereof an effective amount of a composition comprising Biochanin A, genistein, formononetin and daidzein, wherein the composition comprises 80%-96% Biochanin A, 1%-12% genistein, 1%-5% formononetin and 1%-5% of daidzein, wherein the effective amount includes 1.0-6.0 mg of total isoflavones, and the composition is administered via a route to avoid first-pass gastrointestinal and hepatic effects, and to avoid colonic bacterial metabolism, wherein the climacteric symptoms are selected from the group consisting of:

• a. hot flashes;
• b. vaginal atrophy;
• c. vaginal dryness;
• d. diaphoresis;
• e. night sweat;
• f. urinary tract symptoms;
• and
• g. sleep disturbance.