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US 10,307,443 B2Granted
Micronized wharton's jelly
AssigneeMiMedx Group, Inc.
InventorsRandall Spencer, Somaly Sith, Tom Koob
Life of this patent
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AssigneeMiMedx Group, Inc.
InventorsRandall Spencer, Somaly Sith, Tom Koob
Estimating the term…
The present invention provides compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste, suitable for delivery into the space adjacent the articular surface cartilage injured region of a subject. The micronized Wharton's jelly when employed at sufficient concentrations can be hydrated into a gel or paste and administered topically, or it can be injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized in accordance with the present invention.
A method for inducing hyaline cartilage formation in a patient in need thereof, said method comprising introducing a composition comprising Wharton's jelly including one or more growth factors found in Wharton's jelly into a joint of said patient, wherein said composition is substantially free of umbilical cord tissue.
Dependencies are inferred from the claim text.