Pharmaceutical formulations of nitrite and uses thereof
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorsChristopher Kevil, Anthony Giordano, Douglas R Flanagan, Panayiotis P Constantinides
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Abstract
The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
Claims7
A method for treating peripheral neuropathy in a human, the method comprising orally administering two times per day for at least three days a solid, sustained release pharmaceutical composition comprising about 40 mg of sodium nitrite, or a pharmaceutically acceptable salt thereof, and a binding agent, wherein the pharmaceutical composition is coated with an enteric coating.
Dependencies are inferred from the claim text.