Methods for treatment of vascular endothelial dysfunction using nicotinamide mononucleotide
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsDouglas R. Seals, Lindsey Gano, Natalie Poliektor
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Abstract
This invention is about the compositions and methods for assessing and treating vascular endothelial dysfunction. Various aspects provide a method for treatment of vascular endothelial dysfunction, comprising administering a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient to a subject. In one embodiment the dose is administered to subjects in response to the indicator. In another embodiment the dose is administered chronically to subjects.
Claims21
A method for treatment of vascular endothelial dysfunction, comprising:
- determining an indicator of vascular endothelial dysfunction in a subject, wherein the indicator is selected from a group consisting of:
- endothelium-dependent dilation;
- artery stiffness;
- and aortic pulse wave velocity;
- and
- administering a daily dose of a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient, wherein the composition comprises from about 1 mg to about 25 mg of nicotinamide mononucleotide per kg body weight per day and wherein the composition is administered chronically to said subject in response to the indicator.
A method of decreasing the extent of endothelium-dependent dilation and/or arterial stiffness in a subject, comprising:
- determining the extent of endothelium-dependent dilation and/or arterial stiffness in a subject, wherein the indicator is selected from a group consisting of:
- endothelium-dependent dilation;
- artery stiffness;
- and aortic pulse wave velocity;
- and
- administering a daily dose of a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient wherein the composition comprises from about 1 mg to about 25 mg of nicotinamide mononucleotide per kg body weight per day and wherein the composition is administered chronically to said subject.
A method for modulating endothelium-dependent dilation and/or arterial stiffness in a subject, comprising:
- administering a daily dose of a composition comprising nicotinamide mononucleotide and a pharmaceutical excipient wherein the composition comprises from about 1 mg to about 25 mg of nicotinamide mononucleotide per kg body weight per day and wherein the composition is administered chronically to said subject.
Dependencies are inferred from the claim text.