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US 10,307,432 B2Granted
Stabilized liquid fosaprepitant formulations
AssigneeCipla Limited
InventorsGeena Malhotra, Sarabjit Singh, Abhijit Jadhav
Life of this patent
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Abstract
The present invention relates to stable pharmaceutical compositions of fosaprepitant or a salt thereof in the form of ready-to-use or ready-to-dilute compositions suitable for parenteral administration.
Claims21
A liquid composition comprising:
- fosaprepitant or a salt thereof, an aqueous albumin vehicle, and at least one stabilizer selected from fatty acid metal salts, antioxidants, and chelating agents,
- wherein after storage at 2-8° C. for at least 1 month, aprepitant is present in an amount concentration of no more than 10%.
A liquid composition comprising fosaprepitant or a salt thereof, a solubilizer comprising at least one alcohol, at least one glycol, or a combination thereof, wherein after storage at 2-8° C. for at least 1 month, aprepitant is present in an amount concentration of no more than 10%, wherein the composition is ready-to-use or ready-to-dilute.
Dependencies are inferred from the claim text.