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US 10,307,421 B2Granted
Bromocriptine formulations
AssigneeVeroScience LLC
InventorsAnthony H. Cincotta, Craig Michael Bowe, Paul Clark Stearns, Laura Jean Weston
Life of this patent
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Abstract
The present application describes pharmaceutical formulations of bromocriptine mesylate and methods of manufacturing and using such formulations. The formulations are useful for improving glycemic control in the treatment of type 2 diabetes.
Claims25
A method for the manufacture of a dosage form, comprising:
- processing bromocriptine to reduce its average particle size;
- blending the processed bromocriptine with one or more excipients to form a mixture;
- and
- compressing the mixture to form a solid dosage form, wherein the solid dosage form provides a dissolution profile, when tested in USP Apparatus Type 2 Paddle Method at 50 rpm in 500 mL of 0.1 N hydrochloric acid at about 37° C., wherein at least about 80% of the bromocriptine has been released at about 30 minutes.
1 more element
A method for the manufacture of a dosage form, comprising:
- processing bromocriptine to reduce its average particle size and provide bromocriptine in micronized form;
- blending the bromocriptine with one or more excipients to form a mixture;
- and
- compressing the mixture to form a solid dosage form, wherein the dosage form provides a dissolution profile, when tested in USP Apparatus Type 2 Paddle Method at 50 rpm in 500 mL of 0.1 N hydrochloric acid at about 37° C., wherein at least about 80% of the bromocriptine has been released at about 30 minutes.
1 more element
Dependencies are inferred from the claim text.