US 10,307,416 B2Granted

Oligomer-opioid agonist conjugates

AssigneeNektar Therapeutics

InventorsJennifer Riggs-Sauthier, Bo-Liang Deng, Timothy A. Riley

Life of this patent

Estimating the term…

Abstract

The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.

Claims12

Dependent claims

A compound of the following structure:

wherein n is an integer from 3 to 20.

Dependencies are inferred from the claim text.

Facts

Application: 15/247,472Filed 25 Aug 2016 · continuation
Priority: 12 Mar 2007
Published: US 2016/0130276 A129 Dec 2016
Granted: 4 Jun 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 31/485
Quinolines; Isoquinolines: morphinan derivatives, e.g. morphine, codeine
A61K 31/402
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: 1-aryl substituted,…
A61K 31/4025
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: not condensed and…
A61K 31/439
Having six-membered rings with one nitrogen as the only ring hetero atom: the ring forming part of a bridged ring system, e.g. quinuclidine

Family

Application60/906,387Us provisional application · filed 12 Mar 2007
PCT/US2008/003353Parent of this continuation-in-part · filed 12 Mar 2008
Application61/192,261Us provisional application · filed 16 Sep 2008
Application61/227,399Us provisional application · filed 21 Jul 2009
Application12/558,395Parent of this continuation · filed 11 Sep 2009
Application13/426,521Parent of this continuation · filed 21 Mar 2012
US 8,173,666 B2Parent of this continuation · filed 8 May 2012
Application13/538,540Parent of this continuation · filed 29 Jun 2012
US 8,440,687 B2Parent of this continuation · filed 14 May 2013
Application14/032,780Parent of this continuation · filed 20 Sep 2013
US 8,569,343 B2Parent of this continuation · filed 29 Oct 2013
Application14/581,721Parent of this continuation · filed 23 Dec 2014
US 8,946,285 B2Parent of this continuation · filed 3 Feb 2015
Application14/959,538Parent of this continuation · filed 4 Dec 2015
US 9,233,167 B2Parent of this continuation · filed 12 Jan 2016
US 2016/0375009 A1Pre-grant publication · published 29 Dec 2016
US 9,458,166 B2Parent of this continuation
Application12/558,395Parent of this continuation-in-part
US 2010/0048602 A1Published application
US 2012/0264775 A1Published application
US 2012/0289548 A1Published application
US 2014/0187790 A1Published application
US 2015/0238624 A1Published application
US 2016/0130276 A1Published application
US 10,307,416 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

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Abstract

Facts

Application

15/247,472Filed 25 Aug 2016 · continuation

Priority

12 Mar 2007

Published

US 2016/0130276 A129 Dec 2016

Granted

4 Jun 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 31/485
Quinolines; Isoquinolines: morphinan derivatives, e.g. morphine, codeine
A61K 31/402
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: 1-aryl substituted,…
A61K 31/4025
Having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil: not condensed and…
A61K 31/439
Having six-membered rings with one nitrogen as the only ring hetero atom: the ring forming part of a bridged ring system, e.g. quinuclidine

Family

Application60/906,387Us provisional application · filed 12 Mar 2007

PCT/US2008/003353Parent of this continuation-in-part · filed 12 Mar 2008

Application61/192,261Us provisional application · filed 16 Sep 2008

Application61/227,399Us provisional application · filed 21 Jul 2009

Application12/558,395Parent of this continuation · filed 11 Sep 2009

Application13/426,521Parent of this continuation · filed 21 Mar 2012

US 8,173,666 B2Parent of this continuation · filed 8 May 2012

Application13/538,540Parent of this continuation · filed 29 Jun 2012

US 8,440,687 B2Parent of this continuation · filed 14 May 2013

Application14/032,780Parent of this continuation · filed 20 Sep 2013

US 8,569,343 B2Parent of this continuation · filed 29 Oct 2013

Application14/581,721Parent of this continuation · filed 23 Dec 2014

US 8,946,285 B2Parent of this continuation · filed 3 Feb 2015

Application14/959,538Parent of this continuation · filed 4 Dec 2015

US 9,233,167 B2Parent of this continuation · filed 12 Jan 2016

US 2016/0375009 A1Pre-grant publication · published 29 Dec 2016

US 9,458,166 B2Parent of this continuation

Application12/558,395Parent of this continuation-in-part

US 2010/0048602 A1Published application

US 2012/0264775 A1Published application

US 2012/0289548 A1Published application

US 2014/0187790 A1Published application

US 2015/0238624 A1Published application

US 2016/0130276 A1Published application

US 10,307,416 B2This patent

From the US filing history. Foreign family members aren’t listed.