Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system

A pharmaceutical combination comprising as Components:

• (a) a muscarinic cholinergic receptor agonist (MCRA)
• (b) a non-anticholinergic antiemetic agent (naAEA);
• and
• (c) a muscarinic receptor antagonist selected from the group consisting of the non-selective, peripheral anticholinergic agents (nsPAChAs);
• wherein said MCRA Component (a) is selected from the group consisting of cevimeline and pharmaceutically acceptable salts thereof, milameline and pharmaceutically acceptable salts thereof;
• xanomeline and pharmaceutically acceptable salts thereof, and MK-7622 and pharmaceutically acceptable salts thereof;
• said naAEA Component (b) is selected from the group consisting of ondansetron and pharmaceutically acceptable salts and solvates thereof, domperidone and pharmaceutically acceptable salts and solvates thereof and metoclopramide and pharmaceutically acceptable salt and solvates thereof;
• and said nsPAChA Component (c) is oxybutynin in a transdermal patch.