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US 10,307,390 B2Granted
Method of synthesising sulforaphane
AssigneePharmAgra Labs, Inc.
InventorsSahadeva Reddy Damireddi, Kpakpo Ambroise Akue, Jared K Nelson, Albert Roger Frisbee, Peter Wyatt Newsome
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Abstract
The present invention relates to a method of synthesizing sulforaphane by reacting a compound of formula (A) with an oxidizing agent in an aqueous solvent and in the presence of a catalyst. The invention further provides a method of synthesizing a stabilized complex of sulforaphane and cyclodextrin by mixing the sulforaphane prepared by the methodology defined herein with cyclodextrin in an aqueous solvent.
Claims21
A process for the preparation of a complex of sulforaphane and cyclodextrin, the process comprising:
- (i) reacting, in an aqueous solvent, a compound of formula A:
- with an oxidizing agent and in the presence of a catalyst to form sulforaphane;
- and
- (ii) mixing the sulforaphane from step (i) with cyclodextrin in an aqueous solvent to form a precipitate of the sulforaphane-cyclodextrin complex,
- wherein in step (i) 1 to 2 molar equivalents of oxidizing agent, relative to the compound of formula A, is used.
2 more elements
Dependencies are inferred from the claim text.