Succinate prodrugs for use in the treatment of lactic acidosis or drug-induced side-effects due to Complex I-related impairment of mitochondrial oxidative phosphorylation

A method for treating or preventing lactic acidosis, said method comprising administering an effective amount of a succinate prodrug to the subject,

• wherein said succinate prodrug is a compound of Formula (I)
• or a pharmaceutically acceptable salt thereof, wherein the dotted bond between A and B denotes an optional bond so as to form a ring closed structure, and wherein
• Z is —CH2—CH2—,
• A is —SR, and R is
• B is selected from the group consisting of —O—R′, —SR′″ and —OH;
• and R′ is:
• R′″ is:
• R1 and R3 are independently different or identical and are selected from the group consisting of H, Me, Et, propyl, i-propyl, butyl, iso-butyl, and t-butyl,
• X is selected from the group consisting of O, NH, and S,
• p is an integer and is 1 or 2,
• X5 is selected from the group consisting of —H, —COOH, —C(═O)XR6, and CONR1R3,
• R6 is selected from the group consisting of H, Me, Et, propyl, i-propyl, butyl, iso-butyl, t-butyl, acetyl, acyl, propionyl, and benzoyl,
• R13, R14 and R15 are independently different or identical and are selected from the group consisting of H, Me, Et, propyl, i-propyl, butyl, iso-butyl, t-butyl, —COOH, O-acyl, O-alkyl, N-acyl, N-alkyl, Xacyl, and CH2Xalkyl,
• Rf, Rg and Rh are independently different or identical and are selected from the group consisting of Xacyl, —CH2Xalkyl, —CH2X-acyl and R9,
• R9 is selected from the group consisting of H, Me, Et and O2CCH2CH2COXR8, wherein R8 is selected from the group consisting of H, alkyl, Me, Et, propyl, i-propyl, butyl, iso-butyl, t-butyl, acetyl, acyl, propionyl, and benzoyl,
• alkyl is selected from the group consisting of Me, Et, propyl, i-propyl, butyl, iso-butyl, and t-butyl, and
• acyl is selected from the group consisting of formyl, acetyl, propionyl, isopropionyl, butyryl, tert-butyryl, pentanoyl, and benzoyl.