US 10,307,383 B2 · Cosmetic composition for preventing or ameliorating hypersensitive skin comprising cedrol or derivatives thereof, or pharmaceutically acceptable salts thereof

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating autoimmune diseases having cedrol or a pharmaceutically acceptable salt thereof as an active ingredient. Particularly, the cedrol or the derivative thereof of the present invention inhibits the expression of IL-17A, and in particular, cedrol, cedryl acetate, and cedrene exhibit the effect of delaying the outbreak of psoriasis and treating thereof in a psoriasis animal model. Therefore, these compounds can be used for the treatment of autoimmune diseases mediated by IL-17.

Claims2

Dependent claims

A method of alleviating skin irritation in a subject, comprising:

administering to the subject an effective amount of one or more compounds selected from the group consisting of the compounds represented by the following formulas 1˜3 or a pharmaceutically acceptable salt thereof as an active ingredient,
wherein the skin irritation is due to psoriasis;
and
wherein the skin irritation is one or more selected from the group consisting of keratosis, skin flare, skin pain and skin hemorrhage spots:

1 more element

Dependencies are inferred from the claim text.

Facts

Application

15/945,601Filed 4 Apr 2018

Priority

KR 10-2017-00441765 Apr 2017

Published

US 2018/0289634 A111 Oct 2018

Granted

4 Jun 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 31/045
Medicinal preparations containing organic active ingredients: hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A61K 31/015
Hydrocarbons: carbocyclic
A61K 31/075
Medicinal preparations containing organic active ingredients: ethers or acetals
A61K 31/12
Medicinal preparations containing organic active ingredients: ketones

Cosmetic composition for preventing or ameliorating hypersensitive skin comprising cedrol or derivatives thereof, or pharmaceutically acceptable salts thereof

Life of this patent

Cosmetic composition for preventing or ameliorating hypersensitive skin comprising cedrol or derivatives thereof, or pharmaceutically acceptable salts thereof

Life of this patent

Abstract

Claims2