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US 10,307,382 B2Granted
Transdermal therapeutic system for 5-aminolevulinic acid hydrochloride
AssigneePhotonamic GmbH & Co. KG
InventorsTobias Jung, Michael Horstmann, Gerd Hoffmann
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Abstract
The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.
Claims12
A transdermal therapeutic system, comprising:
- a back layer that is impermeable to an active ingredient;
- an active ingredient-containing polymer matrix;
- and
- a protective layer that can be pulled off;
- wherein the polymer matrix consists of:
- about 28% by weight of crystalline 5-aminolevulinic acid hydrochloride as the active ingredient;
- and
- about 72% by weight of a non-crosslinked polyacrylate adhesive based on acrylic acid, 2-ethylhexyl acrylate, and methyl acrylate;
- wherein the transdermal therapeutic system is a monolithic active ingredient-in-adhesive system;
- and
- wherein the transdermal therapeutic system releases within about four hours, an amount of at least 3 mg 5-aminolevulinic acid hydrochloride.
8 more elements
Dependencies are inferred from the claim text.