Back to results
US 10,307,379 B2Granted
Donepezil transdermal delivery system
AssigneeCorium, Inc.
InventorsEun Soo Lee, Amit K. Jain, Parminder Singh
Life of this patent
Estimating the term…
Abstract
A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.
Claims18
A composition, comprising:
- a drug reservoir comprised of a molar amount of donepezil HCl, an equimolar or less than equimolar amount of a pharmaceutically acceptable alkaline salt, a solvent composition comprising a hydrophilic solvent, and an acrylate copolymer, wherein the alkaline salt is sodium bicarbonate or potassium bicarbonate;
- and
- a skin contact adhesive comprising one or more of (i) triethyl citrate, (ii) sorbitan monolaurate, and (iii) lauryl lactate, wherein reaction of donepezil HCl and the alkaline salt generates a therapeutically effective amount of donepezil base in situ in the drug reservoir when the skin contact adhesive is attached to skin of a subject.
A composition, comprising:
- a drug reservoir comprised of a molar amount of a donepezil salt, an equivalent or less than equivalent amount of a pharmaceutically acceptable alkaline salt, a solvent composition comprising a hydrophilic solvent, and an acrylate copolymer, wherein the alkaline salt is sodium bicarbonate or potassium bicarbonate;
- and
- a skin contact adhesive comprising one or more of (i) triethyl citrate, (ii) sorbitan monolaurate, and (iii) lauryl lactate, wherein reaction of the donepezil salt and the alkaline salt generates a therapeutically effective amount of donepezil base in situ in the drug reservoir when the skin contact adhesive is attached to skin of a subject.
Dependencies are inferred from the claim text.