Compositions containing alpha-2-adrenergic agonist components
AssigneeAllergan, Inc.
InventorsRichard Graham, Peter Bakhit, Orest Olejnik
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Abstract
Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.
Claims8
A therapeutically effective aqueous ophthalmic composition for use in reduction of elevated intraocular pressure in patients with open-angle glaucoma and ocular hypertension comprising:
- a solution containing 0.1% (w/v) of a compound selected from the group consisting of brimonidine, a salt of brimonidine, and an ester of brimonidine,
- wherein the solution further comprises an oxy-chloro preservative and carboxymethyl cellulose,
- wherein the composition has a pH between 7.0-8.0.
Dependencies are inferred from the claim text.