Endoscopic transoral duodenal sleeve applier

An apparatus comprising:

• (a) a body;
• (b) a shaft assembly extending distally from the body;
• (c) a duodenal sleeve assembly configured to be carried in a compressed state;
• (d) at least one retention member having a bias to an open configuration and compressible to a closed configuration, wherein the at least one retention member is configured to releasably secure at least a portion of the duodenal sleeve assembly relative to the shaft assembly when the at least one retention member is in a closed configuration;
• (e) a first actuator positioned onboard the body and operatively configured to deploy a sealing member of the duodenal sleeve assembly relative to the shaft assembly;
• and
• (f) a second actuator positioned onboard the body and operatively configured to deploy at least a portion of a sleeve of the duodenal sleeve assembly relative to the shaft assembly.

A method of using an instrument to deploy a duodenal sleeve assembly, wherein the duodenal sleeve assembly comprises an expandable sealing member, an anchor separate from but connected with the sealing member, and a sleeve secured to the sealing member, wherein the instrument comprises a handle assembly, a shaft assembly extending from the handle assembly, and one or more retention members releasably securing the sleeve assembly relative to the shaft assembly, wherein the handle assembly comprises one or more onboard actuators configured to deploy the duodenal sleeve assembly, the method comprising:

• (a) inserting the shaft assembly transorally through a patient's esophagus and stomach such that a distal end of the shaft assembly and at least a portion of the sleeve is positioned in the patient's duodenum;
• and
• (b) actuating the one or more actuators, wherein the act of actuating the one or more actuators
• (i) unfurls the portion of the sleeve relative to the shaft assembly such that the sleeve lines the interior of the duodenum,
• (ii) releases the one or more retention members to release the sealing member relative to the shaft assembly, wherein the released sealing member seals a proximal end of the sleeve against the mucosa of the duodenum, and
• (iii) releases the one or more retention members to release the anchor relative to the shaft assembly, wherein the released anchor engages the mucosa of the stomach.