Crystallized oxalate decarboxylase and methods of use
AssigneeAllena Pharmaceuticals, Inc.
InventorsJack Greene, Richard Johnson, Dennis Krushinskie, Bhami Shenoy
Life of this patent
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Abstract
Pharmaceutical compositions comprising spray-dried oxalate decarboxylase crystals are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using compositions comprising spray-dried oxalate decarboxylase crystals are also disclosed.
Claims38
A pharmaceutical composition comprising a capsule containing crystals of spray-dried oxalate decarboxylase comprising the amino acid sequence of SEQ ID NO:1 where the thiol moiety at Cys383 is protected by a reaction with a thiol protecting group, wherein the crystals have a Hausner ratio of about 1.00 to about 1.59.
Dependencies are inferred from the claim text.