Method and system for characterizing mouth-associated conditions

A method for characterizing a mouth-associated condition in relation to a first user, the method comprising:

• generating a microbiome composition dataset and a microbiome functional diversity dataset based on microorganism sequences derived from biological samples from a set of users, wherein generating the microbiome composition dataset and the microbiome functional diversity dataset comprises:
• identifying primers for nucleic acid sequences associated with the mouth-associated condition,
• fragmenting nucleic acid material,
• amplifying the fragmented nucleic acid material using the identified primers, and
• determining an alignment of the microorganism sequences to reference sequences associated with the mouth-associated condition;
• receiving a supplementary dataset informative of the mouth-associated condition for the set of users;
• obtaining a set of mouth-associated feature-selection rules correlating the mouth-associated condition to a subset of microbiome composition features and a subset of microbiome functional diversity features;
• generating a feature set based on evaluating the microbiome composition dataset and the microbiome functional diversity dataset against the set of mouth-associated feature-selection rules;
• applying the feature set with the supplementary dataset to generate a characterization model for the mouth-associated condition;
• generating a first characterization of the first user in relation to the mouth-associated condition using the characterization model;
• and
• providing a therapy to the first user based on the first characterization.