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US 10,246,748 B2Granted
Biomarker combinations for colorectal tumors
AssigneeNovigenix SA
InventorsStavros Therianos, Curzio Ruegg, Sylvain Monnier-Benoit, Laura Ciarloni, Sahar Hosseinian
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Abstract
The present invention relates to methods and kits for the detection of predetermined biomarkers for early diagnosis and management of cancer, and in particular, colorectal tumors.
Claims24
A method for detecting IL1B, PTGS2 and at least one of S100A8, LTF, CXCL10, and CACNB4, the method comprising:
- (a) extracting RNA from blood cells in peripheral blood from a selected subject to produce extracted RNA;
- and
- (b) measuring in the extracted RNA the amount of mRNA for each biomarker in one biomarker panel, wherein the biomarker panel consists of from 3 to 29 biomarkers, wherein the 3 to 29 biomarkers comprise IL1B, PTGS2, and at least one of S100A8, LTF, CXCL10, and CACNB4,
- wherein said method does not comprise measuring more than 29 biomarkers.
1 more element
A method for detecting IL1B, PTGS2 and at least one of S100A8, LTF, CXCL10, and CACNB4, the method comprising:
- (a) extracting RNA from blood cells in peripheral blood from a selected subject to produce extracted RNA;
- and
- (b) measuring in the extracted RNA the amount of mRNA for each biomarker in a biomarker panel, wherein the biomarker panel comprises the biomarkers IL1B, PTGS2, and at least one of S100A8, LTF, CXCL10, and CACNB4,
- wherein the subject is at least 50 years old and has not been previously diagnosed or identified as having a colorectal tumor,
- wherein said method does not comprise measuring more than 29 biomarkers.
2 more elements
Dependencies are inferred from the claim text.