US 10,246,715 B1 · CpG-oligodeoxynucleotide, immunogenic composition including the same, and method of inducing immune response by the same

Abstract

A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host is provided. The CpG-ODN includes one or more copies of the sequences of GTCGTT, one or more copies of the sequences of GTT and one or more copies of the sequences of TTTT, wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT. Further, an immunogenic composition including the CpG-ODN and a method of inducing immune response by the same are also provided.

Claims15

Dependent claims

A CpG-oligodeoxynucleotide (CpG-ODN) for inducing a TLR9 activated immune response, a TLR21 activated immune response or a combination thereof in a host, comprising:

one or more copies of the sequence of GTCGTT;
one or more copies of the sequence of GTT;
and
one or more copies of the sequence of TTTT;
wherein at least one copy of the sequence of GTCGTT is encoded between the sequence of GTT and the sequence of TTTT, and
the CpG-ODN comprises the sequence of SEQ ID NO:
1.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/722,949Filed 2 Oct 2017

Published

US 2019/0100756 A14 Apr 2019

Granted

2 Apr 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C12N 15/117
DNA or RNA fragments; Modified forms thereof ; Non-coding nucleic acids having a biological activity: nucleic acids having immunomodulatory…
A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides
A61K 31/711
Compounds having three or more nucleosides or nucleotides: natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to…
A61K 39/39
Medicinal preparations containing antigens or antibodies: characterised by the immunostimulating additives, e.g. chemical adjuvants

CpG-oligodeoxynucleotide, immunogenic composition including the same, and method of inducing immune response by the same

Life of this patent

CpG-oligodeoxynucleotide, immunogenic composition including the same, and method of inducing immune response by the same

Life of this patent

Abstract

Claims15