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AssigneeBaylor College of Medicine
InventorsJian-Ming Lu, Qizhi Yao, Changyi Chen
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Embodiments of the invention concern copolymers and nanoparticles for use as delivery agents for one or more agents for therapy for a medical condition of humans and animals. Some of embodiments of the invention provide new reagents for biomedical research in cell culture, animal models and plants, for example. The copolymers comprise PLGA and PEI and, in some embodiments, also comprise 1-(3-aminopropyl)-4-methylpiperazine (APMP), Fc binding peptide and/or antibody. In certain embodiments, APMP-PLGA-PEI, Fc binding peptide/antibody-PLGA-PEI or Fc binding peptide/antibody-AP-MP-PLGA-PEI nanoparticles comprising one or more therapeutic agents are delivered to an individual in need thereof or used for biomedical research in cell cultures, animal models and plants.
A composition comprising a copolymer consisting of lactide-co-glycolide and PEI, wherein single lactide-co-glycolide units are each conjugated to primary amines of PEI through an amide linkage, wherein the w/w ratio of LGA to PEI is 0.5:1 to 5:1,
A copolymer composition comprising lactide-co-glycolide and PEI, wherein single lactide-co-glycolide units are each conjugated to primary amines of PEI through an amide linkage, and wherein the primary amine concentration is about 40% to about 55%.
Dependencies are inferred from the claim text.