Compositions comprising a polymeric network

A composition comprising a polymeric network having at least one unit of formula (I), (II), and/or (III);

• wherein said composition is obtained by contacting at least one compound A comprising at least two functions selected from the group of function of formula —X—C(═O)—CHR1—C(═O)—R2, —C(═O)—C≡C—R2;
• or —C(═O)—CR1═CR2—NR4R5;
• wherein at least 25% by weight of compounds A have a functionality ≤5, with % by weight relative to the total weight of compounds A;
• with at least one compound B comprising at least one —NH2, or —NH3+ groups, or at least one functional group that generates —NH2 or —NH3+ in situ;
• wherein the ratio R=(sum(functionality of compound A×number of moles of compound A))/(sum(functionality of compound B×number of moles of all compound B)) is <1;
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• wherein faNa denotes the number of moles of —X—C(═O)—CHR1—C(═O)—R2, —C(═O)—C≡C—R2;
• or —C(═O)—CR1═CR2—NR4R5 functions of the at least one compound A, and fbNb denotes the number of moles of —NH2, and/or —NH3+ groups or the number of moles of functional groups which could generate —NH2 or NH3+ in situ, of the at least one compound B;
• R1 is hydrogen or is selected from the group consisting of C1-20alkyl, C2-20alkenyl;
• C2-20alkynyl;
• C6-12aryl, C3-8cycloalkyl;
• C6-12arylC1-20alkyl;
• C3-8cycloalkylC1-20alkyl;
• heteroC1-20alkyl;
• heterocyclyl;
• heterocyclylC1-20alkyl;
• heteroaryl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C3-8cycloalkylC1-20alkyl;
• C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl, optionally comprises one or more heteroatoms in the alkyl, alkenyl, alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be unsubstituted or substituted with one or more Z1;
• each Z1 is independently selected from the group consisting of halogen;
• C1-20alkyl;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• and
• R4 is selected from the group consisting of C1-20alkyl, C2-20alkenyl;
• C2-20alkynyl;
• C6-12aryl, C3-8cycloalkyl;
• C6-12arylC1-20alkyl;
• C3-8cycloalkylC1-20alkyl;
• heteroC1-20alkyl;
• heterocyclyl;
• heterocyclylC1-20alkyl;
• heteroaryl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C3-8cycloalkylC1-20alkyl;
• C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl, optionally comprises one or more heteroatoms in the alkyl, alkenyl, alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be unsubstituted or substituted with one or more Z4;
• each Z4 is independently selected from the group consisting of NR11R12;
• halogen;
• C1-20alkyl;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• or wherein the ratio R=(sum(functionality of compound A×number of moles of compound A ))/(sum(functionality of compound A×number of moles of compound A)+sum(functionality of compound B×number of moles of all compound B)) is <1;
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• when R1 and R4 together with the atom to which they are attached form a 5-, 6-, or 7-membered heterocyclyl or heteroaryl;
• wherein each of said heterocyclyl;
• or heteroaryl;
• can be unsubstituted or substituted with one or more Z5;
• each Z5 is independently selected from the group consisting of C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• halogen;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• C(O)NR11R12;
• and —C(O)R9;
• wherein faNa denotes the number of moles of —X—C(═O)—CHR1—C(═O)—R2, —C(═O)—C≡C—R2;
• or —C(═O)—CR1═CR2—NR4R5 functions of the at least one compound A, and fbNb denotes the number of moles of —NH2, and/or —NH3+ groups or the number of moles of functional groups which could generate —NH2 or NH3+ in situ of the at least one compound B;
• and wherein
• X is selected from O, NR13, or CR14R15;
• or
• X and R3 together form a group R6, wherein R6 is selected from the group consisting of C6-12aryl, heteroaryl or heterocyclyl;
• wherein said C6-12aryl, heteroaryl or heterocyclyl can be unsubstituted or substituted with one or more Z31;
• and Z31 is independently selected from the group consisting of —C(═O)—C≡C—R2;
• —X—C(═O)—CHR1—C(═O)—R2, or —C(═O)—CR1═CR2—NR4R5;
• halogen;
• C1-20alkyl;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• or
• R3 is selected from the group consisting of C1-20alkyl, C2-20alkenyl;
• C2-20alkynyl;
• C6-12aryl, C3-8cycloalkyl;
• C6-12arylC1-20alkyl;
• C3-8cycloalkylC1-20alkyl;
• C1-20alkylC3-8cycloalkylC1-20alkyl;
• C3-8cycloalkylC1-20alkylC3-8cyclo alkyl;
• C1-20alkylC6-12arylC1-20alkyl;
• heteroC1-20alkyl;
• heterocyclyl;
• heterocyclylC1-20alkyl;
• C1-20alkylheterocyclylC1-20alkyl;
• heteroaryl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C3-8cycloalkylC1-20alkyl;
• C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• C1-20alkylC3-8cycloalkylC1-20alkyl;
• C3-8cycloalkylC1-20alkylC3-8cycloalkyl;
• C1-20alkylC6-12arylC1-20alkyl;
• C1-20alkylheterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl, optionally comprises one or more heteroatoms in the alkyl, alkenyl, alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl;
• C2-20alkynyl;
• C6-12aryl, C3-8cycloalkyl;
• C6-12arylC1-20alkyl;
• C3-8cycloalkylC1-20alkyl;
• C1-20alkylC3-8cyclo alkylC1-20alkyl;
• C3-8cycloalkylC1-20alkylC3-8cycloalkyl;
• C1-20alkylC6-12arylC1-20alkyl;
• heteroC1-20alkyl;
• heterocyclyl;
• heterocyclylC1-20alkyl;
• C1-20alkylheterocyclylC1-20alkyl;
• heteroaryl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• wherein said C1-20alkyl, C2-20alkenyl;
• C2-20alkynyl;
• C6-12aryl, C3-8cycloalkyl;
• C6-12arylC1-20alkyl;
• C3-8cycloalkylC1-20alkyl;
• C1-20alkylC3-8cycloalkylC1-20alkyl;
• C3-8cycloalkylC1-20alkylC3-8cycloalkyl;
• C1-20alkylC6-12arylC1-20alkyl;
• heteroC1-20alkyl;
• heterocyclyl;
• heterocyclylC1-20alkyl;
• C1-20alkylheterocyclylC1-20alkyl;
• heteroaryl;
• and heteroarylC1-20alkyl;
• can be unsubstituted or substituted with one or more Z3;
• each Z3 is independently selected from the group consisting of —X—C(═O)—CHR1—C(═O)—R2, —C(═O)—C≡C—R2;
• or —C(═O)—CR1═CR2—NR4R5;
• halogen;
• C1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• L1 is selected from the group consisting of C1-20alkylene, C2-20alkenylene;
• C2-20alkynylene;
• C6-12arylene, C3-8cycloalkylene;
• C6-12aryleneC1-20alkylene;
• C3-8cycloalkyleneC1-20alkylene;
• heteroC1-20alkylene;
• heterocyclylene;
• heterocyclyleneC1-20alkylene;
• heteroarylene;
• and heteroaryleneC1-20alkylene;
• wherein said C1-20alkylene, C2-20alkenylene, C2-20alkynylene, C3-8cycloalkyleneC1-20alkylene;
• C6-12arylC1-20alkylene, heterocyclyleneC1-20alkylene;
• and heteroaryleneC1-20alkylene, optionally comprises one or more heteroatoms in the alkylene, alkenylene, alkynylene moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkylene, C2-20alkenylene;
• C2-20alkynylene;
• C6-12arylene, C3-8cycloalkylene;
• C6-12aryleneC1-20alkylene;
• C3-8cycloalkyleneC1-20alkylene;
• heteroC1-20alkylene;
• heterocyclylene;
• heterocyclyleneC1-20alkylene;
• heteroarylene;
• and heteroaryleneC1-20alkylene;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• wherein said C1-20alkylene, C2-20alkenylene;
• C2-20alkynylene;
• C6-12arylene, C3-8cycloalkylene;
• C6-12aryleneC1-20alkylene;
• C3-8cycloalkyleneC1-20alkylene;
• heteroC1-20alkylene;
• heterocyclylene;
• heterocyclyleneC1-20alkylene;
• heteroarylene;
• and heteroaryleneC1-20alkylene;
• can be unsubstituted or substituted with one or more Z21;
• each Z21 is independently selected from the group consisting of halogen;
• C1-20alkyl;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• R2 is selected from the group consisting of C1-20alkyl, C2-20alkenyl;
• C2-20alkynyl;
• C6-12aryl, C3-8cycloalkyl;
• C6-12arylC1-20alkyl;
• C3-8cycloalkylC1-20alkyl;
• heteroC1-20alkyl;
• heterocyclyl;
• heterocyclylC1-20alkyl;
• heteroaryl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C3-8cycloalkylC1-20alkyl;
• C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl, optionally comprises one or more heteroatoms in the alkyl, alkenyl, alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be unsubstituted or substituted with one or more Z2;
• each Z2 is independently selected from the group consisting of halogen;
• C1-20alkyl;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• L2 is selected from the group consisting of C1-20alkylene, C2-20alkenylene;
• C2-20alkynylene;
• C6-12arylene, C3-8cycloalkylene;
• C6-12aryleneC1-20alkylene;
• C3-8cycloalkyleneC1-20alkylene;
• heteroC1-20alkylene;
• heterocyclylene;
• heterocyclyleneC1-20alkylene;
• heteroarylene;
• and heteroaryleneC1-20alkylene;
• wherein said C1-20alkylene, C2-20alkenylene, C2-20alkynylene, C3-8cycloalkyleneC1-20alkylene;
• C6-12arylC1-20alkylene, heterocyclyleneC1-20alkylene;
• and heteroaryleneC1-20alkylene, optionally comprises one or more heteroatoms in the alkylene, alkenylene, alkynylene moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkylene, C2-20alkenylene;
• C2-20alkynylene;
• C6-12arylene, C3-8cycloalkylene;
• C6-12aryleneC1-20alkylene;
• C3-8cycloalkyleneC1-20alkylene;
• heteroC1-20alkylene;
• heterocyclylene;
• heterocyclyleneC1-20alkylene;
• heteroarylene;
• and heteroaryleneC1-20alkylene;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• wherein said C1-20alkylene, C2-20alkenylene;
• C2-20alkynylene;
• C6-12arylene, C3-8cycloalkylene;
• C6-12aryleneC1-20alkylene;
• C3-8cycloalkyleneC1-20alkylene;
• heteroC1-20alkylene;
• heterocyclylene;
• heterocyclyleneC1-20alkylene;
• heteroarylene;
• and heteroaryleneC1-20alkylene;
• can be unsubstituted or substituted with one or more Z22;
• each Z22 is independently selected from the group consisting of halogen;
• C1-20alkyl;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• or wherein R2 and R4 together with the atom to which they are attached form a 5-, 6-, or 7-membered heterocyclyl or heteroaryl;
• wherein each of said heterocyclyl;
• or heteroaryl;
• can be unsubstituted or substituted with one or more Z6;
• each Z6 is independently selected from the group consisting of C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• halogen;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• R5 is hydrogen or is selected from the group consisting of C1-20alkyl, C2-20alkenyl;
• C2-20alkynyl;
• C6-12aryl, C3-8cycloalkyl;
• C6-12arylC1-20alkyl;
• C3-8cycloalkylC1-20alkyl;
• heteroC1-20alkyl;
• heterocyclyl;
• heterocyclylC1-20alkyl;
• heteroaryl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C3-8cycloalkylC1-20alkyl;
• C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl, optionally comprises one or more heteroatoms in the alkyl, alkenyl, alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be unsubstituted or substituted with one or more Z7;
• each Z7 is independently selected from the group consisting of NR11R12;
• halogen;
• C1-20alkyl;
• C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• C3-8cycloalkylC1-20alkyl;
• heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl;
• haloC1-20alkyl;
• haloC1-20alkyloxy;
• —OR10;
• —SR10;
• —S(O)R9;
• —S(O)2R9;
• —SO2NR11R12;
• nitro;
• —NR10C(O)R9;
• —NR10S(O)2R9;
• —NR10C(O)NR11R12;
• cyano;
• —CO2R10;
• —C(O)NR11R12;
• and —C(O)R9;
• each R9 is independently selected from hydroxyl;
• C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl, optionally comprise one or more heteroatoms in the alkyl, alkenyl or alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• each R10 is independently selected from the group consisting of hydrogen, C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl, optionally comprise one or more heteroatoms in the alkyl, alkenyl or alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• and wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• each R11 and R12 is independently selected from the group consisting of hydrogen;
• C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl, optionally comprise one or more heteroatoms in the alkyl, alkenyl or alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• and wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• or wherein R11 and R12 together with the atom to which they are attached form a 5-, 6-, or 7-membered heterocyclyl;
• R13 is hydrogen or is selected from the group consisting of C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl, optionally comprise one or more heteroatoms in the alkyl, alkenyl or alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• and wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• R14 is hydrogen or is selected from the group consisting of C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl, optionally comprise one or more heteroatoms in the alkyl, alkenyl or alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• and wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2;
• R15 is hydrogen or is selected from the group consisting of C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• wherein said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12arylC1-20alkyl, heterocyclylC1-20alkyl;
• heteroarylC1-20alkyl, optionally comprise one or more heteroatoms in the alkyl, alkenyl or alkynyl moiety, said heteroatoms being each independently selected from O, S and N;
• and wherein at least one carbon atom or heteroatom of said C1-20alkyl, C2-20alkenyl, C2-20alkynyl, C6-12aryl, C3-8cycloalkyl, C6-12arylC1-20alkyl, heteroC1-20alkyl;
• heterocyclyl;
• heteroaryl;
• heterocyclylC1-20alkyl;
• and heteroarylC1-20alkyl;
• can be oxidized to form at least one C═O, C═S, N═O, N═S, S═O or S(O)2.