Antibodies, compounds and derivatives thereof for use in the treatment of male infertility
AssigneeRigshospitalet Copenhagen University Hospital
InventorMartin Blomberg Jensen
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Abstract
The present invention relates to antagonists or inhibitors, which bind selectively to RANKL/OPGbp and regulate the interaction between RANKL/OPGbp and RANK/OPG. In particular, the present invention relates to an antibody or antigen binding domain, fragment or derivative thereof, immunoreactive with a RANKL/OPGbppeptide for use in the treatment, prevention or alleviation of male infertility or reduced male fertility such as oligospermia or azospermia.
Claims14
A method of increasing sperm production in a male subject, comprising:
- selecting a male subject with spermatogenic failure;
- and
- administering to said male subject a therapeutically effective amount of a composition comprising Denosumab or an antigen binding domain thereof, or osteoprotegerin (OPG).
A method of treating oligospermia or azoospermia in a male mammal, or of increasing sperm production in the male mammal, said method comprising administering a therapeutically effective amount of OPG (osteoprotegerin) or a fusion protein comprising OPG to the male mammal, wherein the male mammal has spermatogenic failure.
A method of treating oligospermia or azoospermia in a male mammal, or of increasing sperm production in the male mammal, said method comprising administering a therapeutically effective amount of Denosumab to the male mammal, wherein the male mammal has spermatogenic failure.
Dependencies are inferred from the claim text.