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US 10,246,512 B2Granted
IL-2R beta/common gamma chain antibodies
AssigneeAgency for Science, Technology and Research
InventorsCheng-I Wang, Peter Brauer, Siok Ping Yeo, Hwee Ching Tan, John Edward Connolly
Life of this patent
Estimating the term…
Abstract
Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
Claims6
An isolated antibody or antigen binding fragment, which specifically binds to CD122 and common γ chain (γc), wherein the antibody or antigen binding fragment is an IL-2 receptor agonist, and wherein the antibody or antigen-binding fragment comprises:
- (a) an antigen-binding fragment which binds to CD122, comprising:
- (i) a light chain variable region comprising the
- following CDRs:
- LC-CDR1:
- (SEQ ID NO:
- 2)
- TGTSSDIGHYDFVS
- LC-CDR2:
- (SEQ ID NO:
- 3)
- DINNRPS
- LC-CDR3:
- (SEQ ID NO:
- 4)
- SAYTSSDTLV;
- and
- (ii) a heavy chain variable region comprising the
- following CDRs:
- HC-CDR1:
- (SEQ ID NO:
- 36)
- NYYMH
- HC-CDR2:
- (SEQ ID NO:
- 37)
- AIMPSRGGTSYPQKFQG
- HC-CDR3:
- (SEQ ID NO:
- 38)
- GEYYYDSSGYYY;
- and
- (b) an antigen-binding fragment which binds to common γ chain, comprising:
- (i) a light chain variable region comprising the
- following CDRs:
- LC-CDR1:
- (SEQ ID NO:
- 68)
- RSSQSLLHSNGYNYLD
- LC-CDR2:
- (SEQ ID NO:
- 69)
- LGSNRDS
- LC-CDR3:
- (SEQ ID NO:
- 70)
- MQGTHWPWT;
- and
- (ii) a heavy chain variable region comprising the
- following CDRs:
- HC-CDR1:
- (SEQ ID NO:
- 48)
- GYYWS
- HC-CDR2:
- (SEQ ID NO:
- 49)
- EINHSGSTNYNPSLKS
- HC-CDR3:
- (SEQ ID NO:
- 77)
- SPGGYSGGYFQH.
58 more elements
Dependencies are inferred from the claim text.