Polypeptide, anti-VEGF antibody, and anti-c-Met/anti-VEGF bispecific antibodies comprising the same
AssigneeSamsung Electronics Co., Ltd.
InventorsSeung Hyun Lee, Soo Yeon Jung, Bo Gyou Kim, Seung Ja Oh, Ji Min Lee
Life of this patent
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Abstract
A polypeptide, an anti-VEGF antibody and an anti-c-Met/anti-VEGF bispecific antibody, which includes the polypeptide, a pharmaceutical composition including the antibody, and a method of treating cancer using the antibody.
Claims12
An anti-VEGF antibody or an antigen-binding fragment thereof comprising
- a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 110, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 121, a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 129, a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 137, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 145, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 151.
An anti-c-Met/anti-VEGF bispecific antibody comprising an anti-c-Met antibody that comprises two heavy chains and two light chains and an scFv of the anti-VEGF antibody linked to the C-terminus of each anti-c-Met antibody heavy chain, wherein the anti-c-Met heavy chain comprises
- a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 1, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 2, a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 3;
- the anti-c-Met light chain comprises a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 10, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 11, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 13;
- and the anti-VEGF scFv comprises a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 110, a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 121, a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 129, a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 137, a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 145, and a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 151.
Dependencies are inferred from the claim text.