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US 10,246,499 B2Granted
Composition and method for delivery of BMP-2 amplifier/co-activator for enhancement of osteogenesis
AssigneesFerring B.V., Brookhaven Science Associates, LLC
InventorsPaul Zamora, Brent Lee Atkinson, Xinhua Lin, Louis A. Pena
Life of this patent
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Abstract
A composition comprising a synthetic growth factor analogue comprising a non-growth factor heparin binding region, a linker and a sequence that binds specifically to a cell surface receptor and an osteoconductive material where the synthetic growth factor analogue is attached to and can be released from the osteoconductive material and is an amplifier/co-activator of osteoinduction.
Claims16
A composition comprising:
- a synthetic growth factor analogue having the structure
- wherein Hx is 6-aminohexanoic acid, and
- an osteoconductive material comprising 60-20 wt % hydroxyapatite and 80-40 wt % tricalcium phosphate;
- wherein the synthetic growth factor analogue is bound to and can be released from the osteoconductive material.
1 more element
A kit comprising:
- a vial containing a synthetic growth factor analogue having the structure
- wherein Hx is 6-aminohexanoic acid, and
- a separate container containing an osteoconductive material comprising 60-20 wt % hydroxyapatite and 80-40 wt % tricalcium phosphate.
Dependencies are inferred from the claim text.