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AssigneesLa Trobe University, Monash University, Baylor College of Medicine, Peptides International, Inc.
InventorsRaymond S. Norton, Shih Chieh Chang, Michael W. Pennington, Christine Beeton, Brian J. Smith
Estimating the term…
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a ShK toxin polypeptide and an N-terminal extension comprising an amino acid sequence according to formula (I): wherein X−4 is D, E or other negatively-charged amino acid or derivative thereof, X−3 is E, I, L, S, V, W or a tryptophan derivative, X−2 is any amino acid, X−1 is any amino acid, a is absent or a first additional moiety, and b is absent or a second additional moiety. a-X−4X−3X−2X−1-b(SEQ ID NO: 3) (I)
An analogue of Stichodactyla helianthus toxin ShK comprising an ShK toxin polypeptide and an N-terminal extension selected from the group consisting ESSS (SEQ ID NO:
Dependencies are inferred from the claim text.