US 10,246,490 B2 · Conotoxin peptide κ-CPTX-BTL02, preparation method therefor, and uses thereof

Abstract

Provided is a new conotoxin peptide κ-CPTx-btl02. The conotoxin peptide κ-CPTx-btl02 has derivative polypeptide that has an amino acid sequence indicated by SEQ ID NO:1, or has derivative polypeptide that has an amino acid sequence indicated by SEQ ID NO:1 and that is formed after substitution, addition or deletion of one or more amino acids are performed and has original functions. Also provided is polynucleotide for coding the peptide, comprising a constructed body of the polynucleotide, an expression carrier and transformed cells. A peptide preparation method and uses in the treatment of diseases related to a calcium ion channel.

Claims4

Dependent claims

A method of inhibiting a calcium ion channel, the method comprising contacting the calcium ion channel with a conotoxin peptide κ-CPTx-btl02, wherein the peptide comprises the amino acid sequence of SEQ ID NO:

1, and wherein the peptide contains three pairs of disulfide bonds.

Dependencies are inferred from the claim text.

Facts

Application

15/539,720Filed 26 Dec 2014

Published

US 2018/0162908 A114 Jun 2018

Granted

2 Apr 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 7/08
Linear peptides containing only normal peptide links: having 12 to 20 amino acids
A61K 38/10
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides having 12 to 20 amino acids
C07K 1/00
General methods for the preparation of peptides , i.e. processes for the
C07K 1/061
Using protecting groups or activating agents: using protecting groups

Conotoxin peptide κ-CPTX-BTL02, preparation method therefor, and uses thereof

Life of this patent

Conotoxin peptide κ-CPTX-BTL02, preparation method therefor, and uses thereof

Life of this patent

Abstract

Claims4