Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors

A compound of formula (I)

• wherein
• R1 is a group, optionally substituted by one or more, identical or different Rb1 and/or Rc1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rb1 is independently selected from among —ORc1, —NRc1Rc1, halogen, —CN, —C(O)Rc1, —C(O)ORc1, —C(O)NRc1Rc1, —S(O)2Rc1, —S(O)2NRc1Rc1, —NHC(O)Rc1 and —N(C1-4alkyl)C(O)Rc1;
• each Rc1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd1 and/or Re1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rd1 is independently selected from among, —ORe1, NRe1Re1 halogen, —CN,
• C(O)Re1, —C(O)ORe1, —C(O)NRe1Re1, S(O)2Re1, —S(O)2NRe1Re1, —NHC(O)Re1 and —N(C1-4alkyl)C(O)Re1;
• each Re1 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf1 and/or Rg1, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rf1 is independently selected from among —ORg1, —NRg1Rg1, halogen, —CN, —C(O)Rg1, —C(O)ORg1, —C(O)NRg1Rg1, —S(O)2Rg1, —S(O)2NRg1Rg1, —NHC(O)Rg1 and —N(C1-4alkyl)C(O)Rg1;
• each Rg1 is independently selected from among hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• R2 and R3, each independently, is selected from among hydrogen, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl, wherein this C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl is optionally substituted by one or more, identical or different Rb2 and/or Rc2;
• each Rb2 is independently selected from among —ORc2, —NRc2Rc2, halogen, —CN, —C(O)Rc2, —C(O)ORc2, —C(O)NRc2Rc2, —S(O)2Rc2, —S(O)2NRc2Rc2, —NHC(O)Rc2 and —N(C1-4alkyl)C(O)Rc2;
• each Rc2 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd2 and/or Re2, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rd2 is independently selected from among —ORe2, —NRe2Re2, halogen, —CN, —C(O)Re2, —C(O)ORe2, —C(O)NRe2Re2, —S(O)2Re2, —S(O)2NRe2Re2, —NHC(O)Re2 and —N(C1-4alkyl)C(O)Re2;
• each Re2 independently of one another denotes hydrogen or a group selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-6cycloalkyl, C4-6cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• A is selected from among phenyl and 5-6 membered heteroaryl;
• each R4 is independently selected from among Ra4 and Rb4;
• each Ra4 independently of one another is a group, optionally substituted by one or more, identical or different Rb4 and/or Rc4, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rb4 is independently selected from among —ORc4, —NRc4Rc4, halogen, —CN, —C(O)Rc4, —C(O)ORc4, —C(O)NRc4Rc4, —C(O)NRg4ORc4, —S(O)2Rc4, —S(O)2NRc4Rc4, —NHSO2Rc4, —N(C1-4alkyl)SO2Rc4, —NHC(O)Rc4 and —N(C1-4alkyl)C(O)Rc4;
• each Rc4 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rd4 and/or Re4, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rd4 is independently selected from among —ORe4, —NRe4Re4, halogen, —CN, —C(O)Re4, —C(O)ORe4, —C(O)NRe4Re4, —C(O)NRg4ORe4, —S(O)2Re4, —S(O)2NRe4Re4, —NHC(O)Re4 and —N(C1-4alkyl)C(O)Re4;
• each Re4 independently of one another denotes hydrogen or a group, optionally substituted by one or more, identical or different Rf4 and/or Rg4, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• each Rf4 is independently selected from among —ORg4, —NRg4Rg4, halogen, —CN, —C(O)Rg4, —C(O)ORg4, —C(O)NRg4Rg4, —C(O)NRg4ORg4, —S(O)2Rg4, —S(O)2NRg4Rg4, —NHC(O)Rg4 and —N(C1-4alkyl)C(O)Rg4;
• each Rg4 is independently selected from among hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6haloalkyl, C3-7cycloalkyl, C4-7cycloalkenyl, C6-10aryl, 5-10 membered heteroaryl and 3-10 membered heterocyclyl;
• r denotes the number 0, 1, 2 or 3
• R5 and R6, each independently, is selected from among hydrogen, C1-4alkyl and C1-4haloalkyl;
• n denotes the number 0;
• each R7 is independently selected from among halogen, C1-4alkyl, —CN, C1-4haloalkyl, —OC1-4alkyl and —OC1-4haloalkyl;
• q denotes the number 0, 1, 2 or 3;
• W, X and Y is each independently selected from —N═ and —CH═
• with the proviso that the hydrogen in each —CH═ may be replaced by a substituent R7 if present and that a maximum of two of W, X and Y can be —N═;
• V is oxygen or sulfur;
• or a salt thereof.