Alkyl derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain

A compound of Formula I

• wherein
• R1 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C4-7 alkylcycloalkyl,
• wherein the cycloalkyl in R1, if substituted, also in alkylcycloalkyl, is substituted with substituents selected from the group consisting of —R4′″, halogen, —SR4′″, —CN, haloalkyl, and —NR4′″R4′″,
• wherein the alkyl, alkenyl and alkynyl in R1, if substituted, are substituted with substituents selected from the group consisting of halogen, —CN, and haloalkyl;
• R2 is substituted or unsubstituted monocyclic aryl or substituted or unsubstituted monocyclic heterocyclyl,
• wherein the aryl or heterocyclyl in R2, if substituted, is substituted with substituents selected from the group consisting of —R4, —OR4, halogen, ═O, —OCH2CH2OH, —SR4, —S(O)R4, —S(O)2R4, —CN, haloalkyl, -haloalkoxy, —NR4R4′″, —NO2, —NR4C(O)R4′, —NR4SO2R4′, —C(O)OR4, —C(O)NR4R4′, —NR4C(O)NR4′R4″, —S(O)2NR4R4′, and —NR4S(O)2NR4′R4″,
• R3 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl, substituted or unsubstituted C4-7 alkylcycloalkyl, substituted or unsubstituted C4-7 alkylaryl, substituted or unsubstituted C3-6 aryl, substituted or unsubstituted C3-6 heterocyclyl or substituted or unsubstituted C4-7 alkylheterocyclyl,
• wherein the aryl, heterocyclyl or cycloalkyl in R3, if substituted, also in alkylaryl, alkylcycloalkyl or alkylheterocyclyl, is substituted with substituents selected from the group consisting of —R4, —OR4, halogen, ═O, —OCH2CH2OH, —SR4, —S(O)R4, —S(O)2R4, —CN, haloalkyl, -haloalkoxy, —NR4R4′″, —NO2, —NR4C(O)R4′, —NR4S(O)2R4′, —C(O)OR4, —C(O)NR4R4′, —NR4C(O)NR4′R4′″, —S(O)2NR4R4′, and —NR4S(O)2NR4′R4′″
• and wherein the alkyl, alkenyl and alkynyl as defined in R3, if substituted, are substituted with substituents selected from —OR4, halogen, —CN, and haloalkyl,
• R3′ is hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl or unsubstituted C2-6 alkynyl,
• alternatively R3 and R3′ taken together with the connecting C-atom form an substituted or unsubstituted C3-6 cycloalkyl,
• wherein the cycloalkyl formed by R3 and R3′ taken together with the connecting C-atom, if substituted, is substituted with substituents selected from the group consisting of —R4, —OR4, halogen, ═O, —OCH2CH2OH, —SR4, —S(O)R4, —S(O)2R4, —CN, haloalkyl, -haloalkoxy, —NR4R4′″, —NO2, —NR4C(O)R4′, —NR4S(O)2R4′, —C(O)OR4, —C(O)NR4R4′, —NR4C(O)NR4′R4″, —S(O)2NR4R4′, and —NR4S(O)2NR4′R4″;
• R4, R4′ and R4″ are independently selected from the group consisting of hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl or substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted C3-6 cycloalkyl,
• wherein the cycloalkyl in R4, R4′ or R4″, if substituted, is substituted with substituents selected from the group consisting of —R4′″, halogen, —SR4′″, —CN, haloalkyl, and —NR4′″R4′″,
• wherein the alkyl, alkenyl and alkynyl in R4, R4′ or R4″, if substituted, are substituted with substituents selected from the group consisting of halogen, —CN, and haloalkyl;
• R4′″ is hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl or -Boc;
• optionally as a stereoisomer, a racemate or in form of a mixture of at least two stereoisomers, in any mixing ratio, or a corresponding salt thereof, or a corresponding solvate thereof.