US 10,246,460 B2Granted

Synthesis of trans-8-chloro-5-methyl-1-[4-(pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10B-tetraaza-benzo[E]azulene and crytalline forms thereof

AssigneeHoffmann-La Roche Inc.

InventorsBenno Rothenhaeusler, Rene Trussardi, Fabienne Hoffmann-Emery, Urs Schwitter, Jean-Michel Adam, Olaf Grassmann, Thomas Hartung, Frederic Ran, Ralph Diodone, Christophe Pfleger, Bjorn Bartels

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Abstract

The present invention provides processes to manufacture substituted 1-[4-(Pyridin-2-yloxy)-cyclohexyl]-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes. Also disclosed are compounds useful as intermediates in the methods of the invention.

Claims6

Dependent claims

A process to synthesize compound formula I, comprising reacting compound formula III with compound formula VI

Dependencies are inferred from the claim text.

Facts

Application: 15/172,542Filed 3 Jun 2016 · continuation
Priority: EP 131958645 Dec 2013
Published: US 2016/0280712 A129 Sep 2016
Granted: 2 Apr 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07D 487/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61P 25/00
Drugs for disorders of the nervous system
C07D 243/14
Condensed with carbocyclic rings or ring systems: 1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
C07B 2200/13
Indexing scheme relating to specific properties of organic compounds: crystalline forms, e.g. polymorphs

Family

PCT/EP2014/076041Parent of this continuation · filed 1 Dec 2014
US 2016/0280712 A1Pre-grant publication · published 29 Sep 2016
US 10,246,460 B2This patent

From the US filing history. Foreign family members aren’t listed.

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