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US 10,246,455 B2Granted
Histone deacetylase inhibitors
AssigneesTaipei Medical University, National Health Research Institutes
InventorsJing-Ping Liou, Jang-Yang Chang, Jia-Yi Wang, Yun Yen
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Abstract
Fused bicycle indol, indoline, azoindole, or azoindoline compounds of Formula (I) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same. Further disclosed is a method for treating cancer, e.g., glioma, prostate cancer, and colorectal cancer, with these compounds.
Claims9
A compound of formula (I):
- wherein
- R1 is SO2Ra, in which Ra is phenyl substituted with
- R2 is H;
- R3 is H;
- X is C;
- A is unsubstituted pyridine;
- and
- is a double bond,
- or a pharmaceutically acceptable salt or solvate thereof.
6 more elements
Dependencies are inferred from the claim text.