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US 10,246,446 B2Granted
Blockers of the growth hormone receptor in disease prevention and treatment
AssigneeUniversity of Southern California
InventorsValter D. Longo, Priya Balasubramanian, Nouri Neamati, Min Wei
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Abstract
Compounds and methods for treating diseases or conditions affected by the activity or expression of genes/proteins related to human GH, GHR, STAT5, SOCS, IGF-1, insulin are provided. Monoclonal antibodies for treating diseases or conditions related to growth hormone and growth hormone receptor activity are also provided.
Claims11
A compound having formula I:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is NO2, SO3H, NH2, or halogen, and
- R2 is hydrogen, NO2, SO3H, NH2, or C1-8 alkyl, or halogen.
1 more element
A compound having formula II:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- R1 is hydrogen, C1-8 alkyl, or halogen, and
- R2 is C1-8 alkyl, or halogen.
1 more element
A method inhibiting GH induced phosphorylation STAT5, the method comprising:
- administering to a subject a therapeutically effective amount of a compound selected from the group consisting of:
- and combinations thereof and pharmaceutically acceptable salts thereof;
- wherein:
- R1 is hydrogen, NO2, SO3H, NH3, C1-8 alkyl, or halogen, and
- R2 is hydrogen, NO2, SO3H, NH3, C1-8 alkyl, or halogen.
2 more elements
Dependencies are inferred from the claim text.