1,2-dithiolane and dithiol compounds useful in treating mutant EGFR-mediated diseases and conditions

A compound having formula (I):

• including enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, wherein:
• A is selected from the group consisting of
• with the proviso that when A is
• then Y cannot be N and X2 cannot be H when Y is N;
• Z1 is selected from the group consisting of S, SO, and SO2;
• Z2 is selected from the group consisting of S, SO, and SO2;
• Z3 is selected from the group consisting of SH, SCOR1, SO2R2, and SO3H;
• Z4 is selected from the group consisting of SH, SCOR1, SO2R2, and SO3H;
• n=0, 1, 2, 3, 4;
• W is selected from the group consisting of CO and SO2;
• X1 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and, optionally substituted C1-6 alkoxy;
• X2 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, OR3,
• and the C2-6 sugar alcohols such as ethylene glycol, glycerol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, galacitol frucitol, iditol, inositol, and sorbitol;
• Y is selected from the group consisting of N and C—CN;
• R is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, halogen, C1-6 haloalkyl, C3-7 cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, alkoxyheteroarylalkyl,
• R1a is at each occurrence independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, and C1-6 alkoxy;
• R1 is at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy;
• R2 is at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy;
• R3 is an optionally substituted C1-6 alkyl;
• R4 is at each occurrence independently selected from the group consisting of hydrogen, OH, and OR5;
• q=0, 1, 2, 3, 4, or 5;
• R5 is at each occurrence an optionally substituted C1-6 alkyl;
• two R5 substituents can be joined together with the atoms to which they are bound to form a 5 to 6 membered ring.