Crystal form of neratinib maleate and preparation method therefor
AssigneeCrystal Pharmatech Co., Ltd.
InventorsMinhua Chen, Yanfeng Zhang, Xiaojuan Diao, Xiaoyu Zhang
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Abstract
The present invention relates to novel crystalline forms of Neratinib maleate and the preparation method thereof. The novel crystalline forms of Neratinib maleate in the present invention have high solubility, good stability, good processability, easy post-treatment process and other favorable properties. The preparation method is simple, low cost, and has an important value for future optimization and development of the drug.
Claims25
A maleate crystalline Form C of the compound of Formula (I), wherein the X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 10.9±0.2°, 15.2°±0.2° and 23.5°±0.2°
A tri-maleate crystalline Form A of compound of Formula (I), wherein the X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 5.1°±0.2°, 6.9°±0.2°, 11.4°±0.2°, and 13.9°±0.2°
A tri-maleate crystalline Form B of the compound of Formula (I), wherein the X-ray powder diffraction pattern shows characteristic peaks at 2theta values of 5.4°±0.2°, 13.5°±0.2° and 19.6°±0.2°
Dependencies are inferred from the claim text.