4-(3-cyanophenyl)-6-pyridinylpyrimidine mGlu5 modulators

A method for the treatment of a disorder, comprising administering an effective amount of a compound to a subject in need thereof, wherein the compound is selected from the group consisting of the compounds represented by the following formulae:

• or a pharmaceutically acceptable salt thereof, wherein
• R1 is halogen, optionally substituted C1-C3 alkyl, cyclopropyl, optionally substituted C1-C3 alkoxy, cyano, hydroxyl, nitro or NH2;
• R2 is H or F;
• R3 is H, halogen, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy or cyano;
• R4 is H, halogen, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy, or cyano;
• and
• n is 0-3,
• wherein the disorder is migraine, dystonia, depression, anxiety or amyotrophic lateral sclerosis (ALS).