Triazole compounds as T-type calcium channel blockers

A compound of formula (I)

• wherein
• X represents a ring carbon or a ring nitrogen atom;
• R1 represents
• (C2-6)alkyl;
• (C2-4)alkyl mono-substituted with cyano, or (C1-3)alkoxy;
• (C1-4)fluoroalkyl;
• (C1-3)fluoroalkoxy;
• pentafluoro-sulfanyl;
• (C3-6)cycloalkyl-L1- wherein
• said (C3-6)cycloalkyl optionally contains one ring oxygen atom;
• wherein said (C3-6)cycloalkyl is unsubstituted;
• or mono-substituted with fluoro, (C1-3)alkyl, (C1-3)alkoxy, hydroxy, cyano, or (C1-3)fluoroalkyl;
• or di-substituted with fluoro, or tri-substituted with two fluoro substituents and a (C1-3)alkyl substituent;
• and
• the linker L1 represents a direct bond, (C1-2)alkylene, oxygen, or (C1-2)alkylene-oxy;
• 5- or 6-membered heteroaryl, independently optionally mono-substituted with (C1-3)alkyl;
• —NR11R12, wherein
• R11 and R12 independently represent hydrogen, (C1-3)alkyl, (C2-3)fluoroalkyl, (C3-6)cycloalkyl, (C3-6)cycloalkyl mono- or di-substituted with fluoro, (C3-6)cycloalkyl-(C1-3)alkyl, (C1-3)alkoxy-(C2-3)alkyl;
• or R11 and R12, together with the nitrogen atom to which they are attached to, form a 4- to -6 membered ring which is optionally mono- or di-substituted with fluoro;
• a 2-oxo-pyrrolidinyl group;
• or a morpholinyl group;
• and (R4)n represents one or two optional substituents independently selected from (C1-4)alkyl, (C1-4)alkoxy, (C1-3)fluoroalkyl, (C1-3)fluoroalkoxy, halogen, and cyano;
• or R1 together with (R4)n forms a non-aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring;
• wherein said 5- or 6-membered ring optionally contains one or two heteroatoms independently selected from oxygen and nitrogen;
• wherein said fused 5- or 6-membered non-aromatic ring independently is optionally further mono-substituted with oxo;
• or di-, tri-, or tetra-substituted wherein one substituent is oxo and the remaining are (C1-3)alkyl;
• or R1 together with (R4)n forms an aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring;
• wherein said 5- or 6-membered ring optionally contains one or two nitrogen atoms, wherein said fused 5- or 6-membered aromatic ring independently is optionally further mono- or di-substituted wherein the substituents are independently selected from (C1-4)alkyl, (C3-6)cycloalkyl, (C1)fluoroalkyl, or cyano;
• Y represents a ring carbon or a ring nitrogen atom;
• and
• R2 represents (C1-4)alkyl;
• (C3-6)cycloalkyl;
• (C1-4)alkoxy;
• (C3-6)cycloalkyl-oxy;
• (C1-3)fluoroalkyl;
• (C1-3)fluoroalkoxy;
• (C1-3)alkoxy-(C2-3)alkoxy;
• halogen;
• cyano;
• or —NR21R22, wherein R21 and R22 independently represent hydrogen, or (C1-3)alkyl, or R21 and R22, together with the nitrogen atom to which they are attached to, form a 4- to -6 membered ring optionally mono- or di-substituted with fluoro, or a morpholinyl group;
• and
• (R5)m represents one or two optional substituents independently selected from (C1-4)alkyl;
• (C3-6)cycloalkyl;
• (C1-4)alkoxy;
• halogen;
• cyano;
• (C1-3)fluoroalkyl;
• and (C1-3)fluoroalkoxy;
• or a salt of such a compound.