Indazolyl- and indolyl-benzamide derivatives

A compound of the formula:

• or a pharmaceutically acceptable salt thereof, wherein
• bond “” is a single or a double bond;
• R3 is hydrogen, halogen, cyano, —C(O)OH, —C(O)—O(C1-C6 alkyl), —N(RN)2, C1-C6 alkyl,
• C1-C6 alkoxy, C1-C6 haloalkyl, C3-C7 cycloalkyl, aryl, or heteroaryl, wherein;
• each alkyl, cycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide;
• and each RN is independently hydrogen or —C1-C6 alkyl-;
• R4 and R5 are independently hydrogen or halogen;
• R6 is halogen or —Z1RZ1, and wherein
• Z1 is —O—, —NH—, —S(O)p—, or —S(O)2NH—, wherein p is 0, 1 or 2;
• and
• RZ1 is a C1-C14 alkyl group where up to five of the carbon atoms in the alkyl group are optionally replaced independently by R22, carbonyl, ethenyl, ethynyl or a moiety selected from N, O, S, SO2, and SO, with the proviso that two O atoms, two S atoms, or an O and S atom are not immediately adjacent to each other, and
• R22 is heteroaryl, aryl, saturated or unsaturated C3-C10 cycloalkyl, or saturated or unsaturated C2-C10 heterocycloalkyl, wherein each aryl, heteroaryl, saturated or unsaturated cycloalkyl, or saturated or unsaturated heterocycloalkyl, independently, is optionally substituted with at least one group, which independently is hydroxy, halo, amino, cyano, carboxy, carboxamido, nitro, oxo, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, (C1-C6)alkoxy, or mono- or di-(C1-C10)alkylamino;
• and wherein each is optionally fused to a C6-C10 aryl group, C5-C8 saturated cyclic group, or a C5-C10 heterocycloalkyl group;
• and wherein RZ1 optionally substituted at any available position independently with C1-C10 alkyl, C1-C10 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, —SH, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, C1-C6 alkoxy, C2-C10 alkenyloxy, C2-C10 alkynyloxy, mono- or di-(C1-C10)alkylamino, —OC1-C10 alkyl-Z, or R23, wherein
• Z is OR31 or —N(R30)2, wherein
• each R30 is independently hydrogen or C1-C6 alkyl, or N(R30)2 represents pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, 1,3- or 1,4-diazepanyl, or morpholinyl, each of which is optionally substituted with hydroxy, amino, aminoalkyl, C1-C6 alkyl, mono- or di(C1-C6)alkylamino, C1-C6 alkoxy, or halogen;
• R31 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroaryl, or C1-C6 acyl;
• R23 is heteroaryl, aryl, saturated or unsaturated C5-C10 cycloalkyl, or saturated or unsaturated C5-C10 heterocycloalkyl, and each is optionally substituted with at least one group which is independently hydroxy, oxo, halo, amino, cyano, nitro, —SH, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, C1-C6 alkoxy, or mono- or di-(C1-C10)alkylamino;
• R9 and R10 are independently hydrogen or C1-C8 alkyl;
• or R9 and R10 taken together with the carbon atom to which they are attached form C3-C8 cycloalkyl;
• R1 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C1-C10 alkoxy, mono- or di-(C1-C10)alkylamino, C1-C10 alkoxy(C1-C10)alkyl, hydroxy(C1-C10) alkoxy, or amino(C1-C10)alkoxy-;
• R41 is a group of the formula
• wherein
• R1 and R2 are independently H, hydroxy, C2-C6 alkenyl, C2-C6 alkynyl, heteroaryl, aryl, C3-C8 cycloalkyl, heterocycloalkyl, wherein
• each cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide;
• X4 is oxygen;
• X is N or CRC;
• and
• Y is N or CRC;
• each RC is independently is hydrogen, halogen, cyano, nitro, —C(O)RC1, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C10)alkyl, heterocycloalkyl, aryl, or heteroaryl, wherein
• each alkyl, aryl, cycloalkyl, heterocycloalkyl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, cyano, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, carboxamide, heterocycloalkyl, aryl, or heteroaryl, wherein the aryl and heteroaryl groups are optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, halo(C1-C6)alkyl, or carboxamide;
• RC1 is —C1-C6 alkyl, —ORC2, or —N(RCN)2, wherein
• RC2 is —H, C1-C10 alkyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• each RCN is independently —H, C1-C10 alkyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, heterocycloalkyl, C1-C6 acyl, aryl, or heteroaryl, wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide.