US 10,246,411 B2Granted

(Z)-3,4,5-trimethoxystyrylbenzenesulfonamides as potential anticancer agents

AssigneeCouncil of Scientific and Industrial Research

InventorsAhmed Kamal, Mahesh Rasala, Challa Ratna Reddy, Gajjela Bharath Kumar, Visweswara Sastry, Anver Basha Shaik, Vangala Santhosh Reedy

Life of this patent

Estimating the term…

Abstract

This present invention relates to (Z)-3,4,5-Trimethoxystyrylbenzenesulfonamides of general formula A. The invention also provides the synthesis of (Z)-3,4,5-trimethoxystyrylbenzenesulfonamides useful as potential antitumor agents against human cancer cell lines and a process for the preparation thereof.

Claims5

Dependent claims

A (Z)-3,4,5-trimethoxystyryl benzenesulfonamide of general formula A

wherein, X═H, F, OCH3, NH2, or OH;
and R═H, Cl, F, OCH3, NH2, NO2, OH, trifluoromethyl, trifluoromethoxy, methyl, or tert-butyl.

A (Z)-3,4,5-trimethoxystyryl benzenesulfonamide selected from the group consisting of:

(Z)-4-methoxy-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9a)
(Z)-3,4-dimethoxy-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9b)
(Z)-4-chloro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9c)
(Z)-3-chloro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9d)
(Z)-3,4-dichloro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9e)
(Z)-4-fluoro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9f)
(Z)-4-tert-butyl-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9g)
(Z)-4-nitro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9h)
(Z)-4-amino-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9i)
(Z)-3-(trifluoromethyl)-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9J)
(Z)-3-(trifluoromethoxy)-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9k)
(Z)-4-(trifluoromethyl)-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9l)
(Z)-4-(trifluoromethoxy)-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9m)
(Z)-3-nitro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9n)
(Z)-3-amino-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9o)
(Z)-3-fluoro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9p)
(Z)-3-tert-butyl-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9q)
(Z)-3-fluoro-4-methoxy-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9r)
(Z)-3-hydroxy-4-methoxy-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9s)
(Z)-4-methoxy-3-nitro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9t)
(Z)-3,4,5-trimethoxy-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9u)
(Z)-4-methyl-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9v)
(Z)-4-hydroxy-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9w)
(Z)-3,4-difluoro-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9x)
(Z)-3-chloro-4-methoxy-N-(2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (9y)
(Z)-4-methoxy-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10a)
(Z)-3,4-dimethoxy-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10b)
(Z)-4-chloro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10c)
(Z)-3-chloro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10d)
(Z)-3,4-dichloro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10e)
(Z)-4-fluoro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10f)
(Z)-4-tert-butyl-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10g)
(Z)-4-nitro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10h)
(Z)-4-amino-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10i)
(Z)-3-(trifluoromethyl)-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10j)
(Z)-3-(trifluoromethoxy)-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10k)
(Z)-4-(trifluoromethyl)-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10l)
(Z)-4-(trifluoromethoxy)-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10m)
(Z)-3-nitro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10n)
(Z)-3-amino-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10o)
(Z)-3-fluoro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10p)
(Z)-3-tert-butyl-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10q)
(Z)-3-fluoro-4-methoxy-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10r)
(Z)-3-hydroxy-4-methoxy-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10s)
(Z)-4-methoxy-3-nitro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10t)
(Z)-3-amino-4-methoxy-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10u)
(Z)-3,4,5-trimethoxy-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10v)
(Z)-4-methyl-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10w)
(Z)-3,4-difluoro-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10x)
(Z)-3-chloro-4-methoxy-N-(3-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (10y)
(Z)-4-methoxy-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11a)
(Z)-3,4-dimethoxy-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11b)
(Z)-4-chloro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11e)
(Z)-3-chloro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11d)
(Z)-3,4-dichloro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11e)
(Z)-4-fluoro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11f)
(Z)-4-tert-butyl-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11g)
(Z)-4-nitro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11h)
(Z)-4-amino-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11i)
(Z)-3-(trifluoromethyl)-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11j)
(Z)-3-(trifluoromethoxy)-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11k)
(Z)-4-(trifluoromethyl)-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11l)
(Z)-4-(trifluoromethoxy)-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11m)
(Z)-3-nitro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11n)
(Z)-3-amino-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11o)
(Z)-3-fluoro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11p)
(Z)-3-tert-butyl-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11q)
(Z)-3-fluoro-4-methoxy-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11r)
(Z)-3-hydroxy-4-methoxy-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11s)
(Z)-4-methoxy-3-nitro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11t)
(Z)-3-amino-4-methoxy-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11u)
(Z)-3,4,5-trimethoxy-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11v)
(Z)-4-methyl-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11w)
(Z)-3,4-difluoro-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11x)
(Z)-3-chloro-4-methoxy-N-(4-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (11y)
(Z)-4-methoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12a)
(Z)-3,4-dimethoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12b)
(Z)-4-chloro-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12c)
(Z)-3-chloro-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12d)
(Z)-3,4-dichloro-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12e)
(Z)-4-fluoro-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12f)
(Z)-4-tert-butyl-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12g)
(Z)—N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (12h)
(Z)-4-amino-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12i)
(Z)—N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (12j)
(Z)—N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy) benzenesulfonamide (12k)
(Z)—N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (12l)
(Z)—N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (12m)
(Z)—N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (12n)
(Z)-3-amino-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12o)
(Z)-3-fluoro-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12p)
(Z)-3-tert-butyl-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12q)
(Z)-3-fluoro-4-methoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12r)
(Z)-3-hydroxy-4-methoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12s)
(Z)-4-methoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (12t)
(Z)-3-amino-4-methoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12u)
(Z)-3,4,5-trimethoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12v)
(Z)—N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (12w)
(Z)-3,4-difluoro-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12x)
(Z)-3-chloro-4-methoxy-N-(2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (12y)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (13a)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (13b)
(Z)-4-chloro-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (13c)
(Z)-3-chloro-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (13d)
(Z)-3,4-dichloro-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (13e)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-fluorobenzenesulfonamide (13f)
(Z)-4-tert-butyl-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (13g)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (13h)
(Z)-4-amino-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (13i)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (13j)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3(trifluoromethoxy) benzenesulfonamide (13k)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl) benzenesulfonamide (13l)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)Benzenesulfonamide (13m)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (13n)
(Z)-3-amino-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (13o)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-fluorobenzenesulfonamide (13p)
(Z)-3-tert-butyl-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (13q)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-fluoro-4-methoxyBenzenesulfonamide (13r)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-hydroxy-4-methoxy Benzenesulfonamide (13s)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitro Benzenesulfonamide (13t)
(Z)-3-amino-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxyBenzenesulfonamide (13u)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxyBenzenesulfonamide (13v)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methyl benzene sulfonamide (13w)
(Z)—N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4-difluoro Benzenesulfonamide (13x)
(Z)-3-chloro-N-(2,3-dimethoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzene sulfonamide (13y)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy benzene sulfonamide (14a)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (14b)
(Z)-4-chloro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14c)
(Z)-3-chloro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl) phenyl)benzenesulfonamide (14d)
(Z)-3,4-dichloro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14e)
(Z)-4-fluoro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14f)
(Z)-4-tert-butyl-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14g)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (14h)
(Z)-4-amino-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14i)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (14j)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (14k)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (14l)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (14m)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (14n)
(Z)-3-amino-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14o)
(Z)-3-fluoro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14p)
(Z)-3-tert-butyl-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14q)
(Z)-3-fluoro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (14r)
(Z)-3-hydroxy-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-ethoxybenzenesulfonamide (14s)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (14t)
(Z)-3-amino-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-ethoxybenzenesulfonamide (14u)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (14v)
(Z)—N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (14w)
(Z)-3,4-difluoro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (14x)
(Z)-3-chloro-N-(3-hydroxy-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (14y)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (15a)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (15b)
(Z)-4-chloro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15c)
(Z)-3-chloro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15d)
(Z)-3,4-dichloro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15e)
(Z)-4-fluoro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15f)
(Z)-4-tert-butyl-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15g)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (15h)
(Z)-4-amino-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15i)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (15j)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (15k)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (15l)
(Z)—N-(3-fluom-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (15m)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (15n)
(Z)-3-amino-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15o)
(Z)-3-fluoro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15p)
(Z)-3-tert-butyl-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15q)
(Z)-3-fluoro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (15r)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-hydroxy-4-methoxybenzenesulfonamide (15s)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (15t)
(Z)-3-amino-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (15u)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (15v)
(Z)—N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methyl benzenesulfonamide (15w)
(Z)-3,4-difluoro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (15x)
(Z)-3-chloro-N-(3-fluoro-2-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (15y)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (16a)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (16b)
(Z)-4-chloro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16c)
(Z)-3-chloro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)Benzenesulfonamide (16d)
(Z)-3,4-dichloro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16e)
(Z)-4-fluoro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16f)
(Z)-4-tert-butyl-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16g)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (16h)
(Z)-4-amino-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16i)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (16j)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (16k)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (16l)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy) benzenesulfonamide (16m)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (16n)
(Z)-3-amino-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl) benzenesulfonamide (16o)
(Z)-3-fluoro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16p)
(Z)-3-tert-butyl-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16q)
(Z)-3-fluoro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (16r)
(Z)-3-hydroxy-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (16s)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (16t)
(Z)-3-amino-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (16u)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (16v)
(Z)—N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (16w)
(Z)-3,4-difluoro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (16x)
(Z)-3-chloro-N-(2-hydroxy-3-methoxy-5-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (16y)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (17a)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (17b)
(Z)-4-chloro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17c)
(Z)-3-chloro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17d)
(Z)-3,4-dichloro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17e)
(Z)-4-fluoro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17f)
(Z)-4-tert-butyl-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17g)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (17h)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (17i)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (17j)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (17k)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (17l)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (17m)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (17n)
(Z)-3-amino-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17o)
(Z)-3-fluoro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17p)
(Z)-3-tert-butyl-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17q)
(Z)-3-fluoro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (17r)
(Z)-3-hydroxy-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (17s)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (17t)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (17u)
(Z)—N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (17v)
(Z)-4-hydroxy-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17w)
(Z)-3,4-difluoro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (17x)
(Z)-3-chloro-N-(2-hydroxy-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (17y)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (18a)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (18b)
(Z)-4-chloro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18c)
(Z)-3-chloro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18d)
(Z)-3,4-dichloro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18e)
(Z)-4-fluoro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18f)
(Z)-4-tert-butyl-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18g)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (18h)
(Z)-4-amino-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18i)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (18j)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (18k)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (18l)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (18m)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (18n)
(Z)-3-amino-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18o)
(Z)-3-fluoro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18p)
(Z)-3-tert-butyl-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18q)
(Z)-3-fluoro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (18r)
(Z)-3-hydroxy-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (18s)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (18t)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (18u)
(Z)—N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (18v)
(Z)-4-hydroxy-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18w)
(Z)-3,4-difluoro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (18x)
(Z)-3-chloro-N-(4-hydroxy-5-methoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (18y)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (19a)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (19b)
(Z)-4-chloro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19c)
(Z)-3-chloro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19d)
(Z)-3,4-dichloro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19e)
(Z)-4-fluoro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19f)
(Z)-4-tert-butyl-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19g)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (19h)
(Z)-4-amino-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19i)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (19j)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy) benzenesulfonamide (19k)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (19l)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (19m)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (19n)
(Z)-3-amino-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19o)
(Z)-3-fluoro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19p)
(Z)-3-tert-butyl-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19q)
(Z)-3-fluoro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (19r)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-hydroxy-4-methoxybenzenesulfonamide (19s)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (19t)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (19u)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (19v)
(Z)—N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-hydroxybenzenesulfonamide (19w)
(Z)-3,4-difluoro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (19x)
(Z)-3-chloro-N-(2-fluoro-3-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (19y)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (20a)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (20b)
(Z)-4-chloro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20c)
(Z)-3-chloro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20d)
(Z)-3,4-dichloro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl) benzenesulfonamide (20e)
(Z)-4-fluoro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20f)
(Z)-4-tert-butyl-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20g)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (20h)
(Z)-4-amino-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20i)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (20j)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (20k)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (20l)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (20m)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (20n)
(Z)-3-amino-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20o)
(Z)-3-fluoro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20p)
(Z)-3-tert-butyl-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20q)
(Z)-3-fluoro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (20r)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-hydroxy-4-methoxybenzenesulfonamide (20s)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (20t)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (20u)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (20v)
(Z)—N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-hydroxybenzenesulfonamide (20w)
(Z)-3,4-difluoro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (20x)
(Z)-3-chloro-N-(3-fluoro-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (20y)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (21a)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (21b)
(Z)-4-chloro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21c)
(Z)-3-chloro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21d)
(Z)-3,4-dichloro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21e)
(Z)-4-fluoro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21f)
(Z)-4-tert-butyl-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21g)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (21h)
(Z)-4-amino-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21i)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (21j)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (21k)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (21l)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (21m)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (21n)
(Z)-3-amino-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21o)
(Z)-3-fluoro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21p)
(Z)-3-tert-butyl-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21q)
(Z)-3-fluoro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (21r)
(Z)-3-hydroxy-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (21s)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (21t)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (21u)
(Z)—N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (21v)
(Z)-4-hydroxy-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21w)
(Z)-3,4-difluoro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (21x)
(Z)-3-chloro-N-(3-hydroxy-2-methoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (21y)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (22a)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (22b)
(Z)-4-chloro-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (22c)
(Z)-3-chloro-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (22d)
(Z)-3,4-dichloro-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (22e)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-fluorobenzenesulfonamide (22f)
(Z)-4-tert-butyl-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (22g)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (22h)
(Z)-4-amino-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (22i)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (22j)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (22k)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (22l)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (22m)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (22n)
(Z)-3-amino-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (22o)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-fluorobenzenesulfonamide (22p)
(Z)-3-tert-butyl-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (22q)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-fluoro-4-methoxybenzenesulfonamide (22r)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3-hydroxy-4-methoxybenzenesulfonamide (22s)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (22t)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (22u)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (22v)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-hydroxybenzenesulfonamide (22w)
(Z)—N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-3,4-difluorobenzenesulfonamide (22x)
(Z)-3-chloro-N-(2,3-dimethoxy-6-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (22y)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (23a)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3,4-dimethoxybenzenesulfonamide (23b)
(Z)-4-chloro-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (23c)
(Z)-3-chloro-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (23d)
(Z)-3,4-dichloro-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (23e)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-fluorobenzenesulfonamide (23f)
(Z)-4-tert-butyl-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (23g)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-nitrobenzenesulfonamide (23h)
(Z)-4-amino-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (23i)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethyl)benzenesulfonamide (23j)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-(trifluoromethoxy)benzenesulfonamide (23k)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethyl)benzenesulfonamide (23l)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-(trifluoromethoxy)benzenesulfonamide (23m)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-nitrobenzenesulfonamide (23n)
(Z)-3-amino-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (23o)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-fluorobenzenesulfonamide (23p)
(Z)-3-tert-butyl-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)benzenesulfonamide (23q)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-fluoro-4-methoxybenzenesulfonamide (23r)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3-hydroxy-4-methoxybenzenesulfonamide (23s)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxy-3-nitrobenzenesulfonamide (23t)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3,4,5-trimethoxybenzenesulfonamide (23u)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methylbenzenesulfonamide (23v)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-hydroxybenzenesulfonamide (23w)
(Z)—N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-3,4-difluorobenzenesulfonamide (23x) and
(Z)-3-chloro-N-(4,5-dimethoxy-2-(3,4,5-trimethoxystyryl)phenyl)-4-methoxybenzenesulfonamide (23y).

372 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/523,205Filed 27 Oct 2015
Priority: IN 3076/DEL/201429 Oct 2014
Published: US 2017/0327462 A116 Nov 2017
Granted: 2 Apr 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07C 311/44
Having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton: having the…
A61P 35/00
Antineoplastic agents
C07C 311/21
Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings: having the nitrogen atom of at least…
C07C 311/29
Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms: having the sulfur atom of at least one…

Family

US 2017/0327462 A1Pre-grant publication · published 16 Nov 2017
US 10,246,411 B2This patent

From the US filing history. Foreign family members aren’t listed.

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