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US 10,245,368 B2Granted
Integrated hybrid bio-artificial liver bioreactor design and method thereof
AssigneeIndian Institute of Technology Kanpur
InventorsAshok Kumar, Apeksha Damania
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Abstract
The present invention relates to the field of bio-artificial liver technology. Particularly, the invention provides an integrated hybrid bio-artificial liver support system that provides the features of artificial liver assist devices with that of bio-artificial liver support systems.
Claims10
A hybrid Bioartificial liver bioreactor comprising:
- at least three chambers adapted to be positioned as ax integrated and a single unit including:
- a top chamber, provided with a first inlet/outlet port, comprising a plasma separation membrane configured to separate a blood stream received from a patient into plasma and blood cells;
- a middle chamber, provided with a second inlet/outlet port to connect with the top or a bottom chamber, said middle chamber seeded with hepatocyte cells in a semi-interpenetrating supermacroporous cryogel;
- the bottom chamber provided with a third inlet/outlet port to connect with the top or middle chambers, the bottom chamber configured for plasma collection and reintroduction of said plasma or part thereof to one of said top or middle chambers;
- where said top and middle chambers are configured to be separated in position by a means for filtering, toxic compounds, and
- where said middle and bottom chambers are separated by a means for trapping cellular material from leaking out of said bioreactor.
3 more elements
A hybrid Bioartificial liver bioreactor comprising:
- at least three chambers adapted to be positioned as an integrated and a single unit, the at least three chambers including a top chamber having a top chamber inlet/outlet port, comprising means for separating a blood stream received from a patient into plasma and blood cells,
- a middle chamber, provided with a middle chamber inlet/outlet port to connect with the top or a bottom chamber, said middle chamber seeded with hepatocyte cells in a semi-interpenetrating supermacroporous cryogel, the bottom chamber provided with a bottom chamber inlet/outlet port to connect with the top or middle chambers, the bottom chamber configured for collecting plasma and reintroducing plasma or part thereof to one of said top or middle chambers;
- and
- a filter configured to filter toxic compounds, said filter separating the top and middle chambers;
- and
- a membrane separating the middle and bottom chambers configured to trap cellular material from leaking out of said middle chamber.
3 more elements
Dependencies are inferred from the claim text.