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US 10,245,365 B2Granted
Replenisihing urease in dialysis systems using a urease introducer
AssigneeMedtronic, Inc.
InventorsMartin T. Gerber, Christopher M. Hobot
Life of this patent
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Abstract
An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The sorbent cartridge is configured to allow an amount of urease to be added to the sorbent cartridge. A urease solution can be injected into the sorbent cartridge to replenish the urease containing module, or solid urease can be added to the sorbent cartridge. The sorbent module can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.
Claims23
A method, comprising the steps of:
- detecting an amount of urea directly or indirectly by measuring products proportional to an amount of urea in a sample in a dialysate downstream of a sorbent cartridge;
- wherein the sorbent cartridge contains urease and at least one or more other sorbent materials;
- and
- supplying urease to the sorbent cartridge by a urease introducer if the amount of urea downstream of the sorbent cartridge is above a threshold, wherein the sorbent cartridge is adapted to receive an adjustable amount of urease, wherein the urease introducer comprises any one of a slideable tray and a door.
1 more element
Dependencies are inferred from the claim text.