Contrast agents for applications including perfusion imaging

A method of imaging cancer in a subject, comprising:

• administering to a subject with cancer a contrast agent which comprises an imaging moiety and a compound bound to the imaging moiety, scanning the patient using diagnostic imaging to produce an image of at least a portion of the cancer, wherein the contrast agent has a structure as in Formula (II),
• wherein:
• J is selected from N(R27) S, O, C(═O), C(═O)O, NHCH2CH2O, a bond, or C(═O)N(R27);
• K and L, when present, are independently selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, alkyl, heteroaryl, and an imaging moiety, each of which is optionally substituted;
• M is selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, alkyl, heteroaryl, and an imaging moiety, each of which is optionally substituted, or
• L and M, together with the atom to which they are attached, form a ring, optionally substituted;
• Q is halo or haloalkyl;
• n is 0, 1, 2, or 3;
• R21, R22, R23, R24, R25, R26, and R27 are independently selected from hydrogen, alkyl,
• optionally substituted, and an imaging moiety;
• R29 is alkyl, optionally substituted;
• and
• Y is selected from a bond, carbon, and oxygen;
• provided that when Y is a bond, K and L are
• absent and M is selected from aryl and heteroaryl, each of which is optionally substituted;
• and
• provided that when Y is oxygen, K and L are absent and M is selected from hydrogen, alkoxyalkyl,
• aryl, alkyl, and heteroaryl, each of which is optionally substituted,
• wherein at least one imaging moiety is present in Formula (II) and is 18F.