Composition having dye and conjugate of polyethyleneglycol and additive and contrast agent for photoacoustic imaging having the same

A contrast agent suitable for photoacoustic imaging, comprising:

• a compound represented by formula (1), (5), (6), or (7);
• and an additive, which interacts with the compound, wherein the additive is at least one selected from the group consisting of an α-cyclodextrin, a β-cyclodextrin, a hydroxypropyl-β-cyclodextrin, and a γ-cyclodextrin:
• wherein R301 to R312 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, —PO3T301, a substituted or unsubstituted phenyl group, thiophene group, or pyridinyl group and a linear or branched alkyl group having 1 to 18 carbon atoms;
• T301 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
• R31 to R34 are each independently selected from the group consisting of a hydrogen atom and a linear or branched alkyl group having 1 to 18 carbon atoms;
• A31, B31 and B32 each independently represent a linear or branched alkylene group having 1 to 18 carbon atoms;
• L31 to L37 are each independently selected from the group consisting of CH and CR35 and may form a 4- to 6-membered ring;
• R35 is selected from the group consisting of a linear or branched alkyl group having 1 to 18 carbon atoms, a halogen atom, a substituted or unsubstituted phenyl group, pyridinyl group, or benzyl group, ST302 and a linear or branched alkylene group having 1 to 18 carbon atoms;
• T302 is selected from the group consisting of a linear or branched alkyl group having 1 to 18 carbon atoms, a substituted or unsubstituted phenyl group and a linear or branched alkylene group having 1 to 18 carbon atoms;
• Q31 is selected from the group consisting of —CONT31-, —NT31CO—, —NT31(C═O) NT31-, —NT31(C═S) NT31-, —NT31(C═O)O—, —O—, —S—, —S(═O)2NT31-, —OP(═O)(OT31)O—, —S—S—, —CT31=N—, —CT31=N—NH—, —CT31=N—O—, —CT31=N—NH—O—, —CONT31-R37—(C═O)O—, —CONT31-R37—CONT31-, formula (2) and formula (3);
• T31 is selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 5 carbon atoms;
• R37 is selected from the group consisting of —CH(CO2T37)-, —CH(CH2CO2T37)- and a linear or branched alkylene group having 1 to 18 carbon atoms;
• T37 is selected from the group consisting of a hydrogen atom, a sodium atom, a potassium atom and an alkyl group having 1 to 5 carbon atoms;
• R38 is selected from the group consisting of an alkyl group having 1 to 18 carbon atoms, a hydrogen atom, —OCH3, —NH2, —OH, —CO2T38, —S(═O)2OT38, —P(═O)(OT38)2 and —OP(═O)(OT38)2;
• T38 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
• R39 is selected from the group consisting of a hydrogen atom, —OCH3, —NH2, —OH, —S(═O)2OT39, —CO2T39, —P(═O)(OT39)2, —CONH—CH(CO2T39)-CH2(C═O)OT39, —CONH—CH(CO2T39)-CH2CH2(C═O)OT39 and —OP(═O)(OT39)2;
• T39 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
• q is an integer from 1 to 20;
• n is an integer from 2 to 250: