Immunomodulatory pharmaceutical compositions and methods of use thereof
AssigneeEnzo Biochem, Inc.
InventorsAnte Tocilj, Jack Coleman, Elazar Rabbani, James J. Donegan
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Abstract
Provided are immunomodulatory pharmaceutical compositions that include alpha-synuclein, and at least one preselected antigen, such as at least one preselected peptide antigen or immunogen. Also provided are methods for modulating immune activity toward at least one preselected antigen in an at least substantially antigen-specific manner that includes administering such a composition to a human patient or a non-human mammalian subject.
Claims26
An immunomodulatory pharmaceutical composition comprising:
- (a) at least substantially pure alpha-synuclein protein;
- and
- (b) at least one preselected antigen or immunogen, which is not a human or non-human mammalian alpha-synuclein protein or a fragment thereof.
A method for manufacturing an immunomodulatory pharmaceutical composition comprising the steps of:
- providing at least substantially purified human or non-human mammalian alpha-synuclein protein;
- providing at least one preselected antigen or immunogen, which is not a human or non-human mammalian alpha-synuclein protein or a fragment thereof;
- and
- mixing the at least substantially purified mammalian alpha-synuclein protein and the at least one preselected antigen or immunogen.
Dependencies are inferred from the claim text.