Multivalent recombinant avian herpes viruses and vaccines for immunizing avian species
AssigneeCeva Sante Animale
InventorsAyumi Fujisawa, Mayumi Kubomura, Sakiko Saeki, Shuji Saito
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Abstract
The present invention relates to a recombinant avian herpes virus, which comprises at least two recombinant nucleotide sequences, each recombinant nucleotide sequence encoding a distinct antigenic peptide, wherein the at least two recombinant nucleotide sequences are inserted into distinct non-coding regions of the viral genome chosen among the region located between UL44 and UL45, the region located between UL45 and UL46, the region located between US10 and SORF3, and the region located between SORF3 and US2.
Claims8
A recombinant avian herpes virus which comprises (i) a recombinant nucleotide sequence encoding a F protein of Newcastle Disease Virus or an immunogenic fragment thereof, under the control of a Pec promoter, inserted into a non-coding region of the viral genome located between UL45 and UL46;
- and (ii) a recombinant nucleotide sequence encoding a VP2 protein of Infectious Bursal Disease Virus or an immunogenic fragment thereof, under the control of a mCMV IE1 promoter, inserted into a non-coding region of the viral genome located between UL44 and UL45.
Dependencies are inferred from the claim text.