Non-specific delayed-type hypersensitivity response to treat herpes simplex virus infection

A method of treating herpes simplex virus (HSV) infection comprising:

• an administering step comprising:
• applying a topical immunosensitizer to the skin of a person infected with HSV at a time when the person is not having an HSV outbreak, or applying a topical immunosensitizer to the skin of a person infected with HSV during an HSV outbreak wherein the applying is at a site other than a site of an HSV lesion;
• wherein the method does not further comprise (i) applying a topical immunosensitizer to the skin of a person infected with HSV on an HSV lesion at a time of an HSV outbreak in the person;
• or (ii) intradermally injecting a recall antigen into a person infected with HSV in an HSV lesion at the time of an HSV outbreak in the person;
• wherein the method reduces the frequency of HSV outbreaks in the person after the administering step;
• wherein the person has had HSV outbreaks before the administering step and is in recognized need of treatment for HSV infection;
• wherein the administering step comprises applying the topical immunosensitizer to skin on the forearm or on the inner aspect of the upper arm of the person;
• wherein the topical immunosensitizer comprises squaric acid dibutyl ester (SADBE);
• and
• wherein the person has herpes labialis.