Antigen specific multi epitope-based anti-infective vaccines
AssigneesLior Carmon, Vaxil Biotherapeutics Ltd.
InventorLior Carmon
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Abstract
The invention provides peptide vaccines comprising the signal peptide domain of selected target antigens of intracellular pathogens. The peptide vaccines of the invention contain multiple class II and class I-restricted epitopes and are recognized and presented by the majority of the vaccinated human population. The invention provides in particular anti tuberculosis vaccines. The invention further provides compositions comprising the vaccines as well as their use to treat or prevent infection.
Claims20
A method of treating a pathogenic infection in a subject in need thereof, comprising administering to the subject any one of:
- (i) an immunogenic composition comprising at least one peptide comprising a signal peptide domain of at least one target protein of said pathogen, wherein said peptide is not longer than 40 amino acids;
- (ii) an enriched T cell population obtained by administering an immunogenic composition comprising at least one peptide comprising a signal peptide domain of at least one target protein of said pathogen to a T cell population in vitro, wherein said peptide is not longer than 40 amino acids.
A method of activating both CD4+ and CD8+ T cells, comprising administering an immunogenic composition comprising at least one peptide comprising a signal peptide domain of at least one target protein of an intracellular pathogen to said T cells, wherein said peptide is not longer than 40 amino acids.
Dependencies are inferred from the claim text.