Gluten-related disorders
AssigneeH.J. Heinz Company Brands LLC
InventorsFrancesca Romana Fasano, Andrea Luigi Budelli
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Abstract
The present invention features compositions and methods for treating gluten-related disorders. We describe compositions comprising one or more metabolites produced by Lactobacillus paracasei CBA L74, International Depository Accession Number LMG P-24778 that reduce cellular entry of gliadin peptides. The compositions may include a physiologically acceptable carrier, for example, a food product or a pharmaceutical carrier. The compositions can be administered to a subject having a gluten-related disorder, for example, celiac disease or gluten sensitivity.
Claims31
A method of treating a subject having a gluten-related disorder, the method comprising:
- administering to the subject an effective amount of a composition comprising a probiotic bacterium Lactobacillus paracasei CBA L74, deposited at the Belgian Coordinated Collections of Micro-organisms (BCCM) Laboratorium voor Microbiologie (LMG) and having International Depository Accession Number LMG P-24778, wherein the probiotic bacterium reduces a symptom of gliadin peptide toxicity.
A method of treating a subject having a gluten-related disorder, the method comprising:
- administering to the subject an effective amount of a composition comprising a fermented food product, wherein the fermented food product has been fermented by probiotic bacterium Lactobacillus paracasei CBA L74, deposited at the Belgian Coordinated Collections of Micro-organisms (BCCM) Laboratorium voor Microbiologie (LMG) and having International Depository Accession Number LMG P-24778, and the fermented food product reduces a symptom of gliadin peptide toxicity.
A method of treating a subject having a gluten-related disorder, the method comprising:
- administering to the subject an effective amount of a composition comprising a culture supernatant of probiotic bacterium Lactobacillus paracasei CBA L74, deposited at the Belgian Coordinated Collections of Micro-organisms (BCCM) Laboratorium voor Microbiologie (LMG) and having International Depository Accession Number LMG P-24778, wherein the culture supernatant reduces a symptom of gliadin peptide toxicity in a subject having a gluten-related disorder, and
- the culture supernatant comprises Lactobacillus paracasei CBA L74 cells and/or one or more sub-cellular bacterial components from Lactobacillus paracasei CBA L74 cells, wherein any Lactobacillus paracasei CBA L74 cells present in the culture supernatant are dead or have been rendered incapable of cell division.
Dependencies are inferred from the claim text.