Back to results
US 10,245,299 B2Granted
Autoassembling peptides for the treatment of pulmonary bulla
Assignee3-D Matrix, Ltd.
InventorsManav Mehta, Hisashi Tsukada, Eun Seok Gil, Karl Gilbert, Satoru Kobayashi
Life of this patent
Estimating the term…
Abstract
Materials and methods for treatment of pulmonary bulla are provided. A peptide comprising between about 7 amino acids and about 32 amino acids in a solution may be introduced to a target site. A hydrogel barrier may be provided at the target site in order to treat the pulmonary bulla.
Claims8
A method of treating a pulmonary bulla in a subject, comprising:
- introducing a delivery device to a target area of the pulmonary bulla of the subject;
- positioning an end of the delivery device in the target area in which a treatment of the pulmonary bulla is desired;
- administering, through the delivery device, a solution comprising an amphiphilic self-assembling peptide comprising between about 7 amino acids and 32 amino acids in an effective amount and in an effective concentration to the target area to form a hydrogel barrier under physiological conditions of the target area to treat the pulmonary bulla;
- removing the delivery device from the target area;
- and
- collapsing the pulmonary bulla prior or subsequent to administering the solution.
3 more elements
A method of treating a pulmonary bulla in a subject, comprising:
- introducing a delivery device to a target area of the pulmonary bulla of the subject;
- positioning an end of the delivery device in the target area in which a treatment of the pulmonary bulla is desired;
- administering, through the delivery device, a solution comprising an amphiphilic self-assembling peptide comprising between about 7 amino acids and 32 amino acids in an effective amount and in an effective concentration to the target area to form a hydrogel barrier under physiological conditions of the target area to treat the pulmonary bulla, wherein the administering the solution comprises administering the solution in a single dose;
- administering the solution until a volume of the target area is filled;
- and
- removing the delivery device from the target area.
3 more elements
A method of treating a pulmonary bulla in a subject, comprising:
- introducing a delivery device to a target area of the pulmonary bulla of the subject;
- positioning an end of the delivery device in the target area in which a treatment of the pulmonary bulla is desired;
- administering, through the delivery device, a solution comprising an amphiphilic self-assembling peptide comprising between about 7 amino acids and 32 amino acids in an effective amount and in an effective concentration to the target area to form a hydrogel barrier under physiological conditions of the target area to treat the pulmonary bulla;
- and
- removing the delivery device from the target area,
- wherein the subject has been diagnosed with at least one of emphysema and chronic obstructive pulmonary disease (COPD) prior to administering the solution comprising the amphiphilic self-assembling peptide.
3 more elements
A method of treating a pulmonary bulla in a subject, comprising:
- introducing a delivery device to a target area of the pulmonary bulla of the subject;
- positioning an end of the delivery device in the target area in which a treatment of the pulmonary bulla is desired;
- administering, through the delivery device, a solution comprising an amphiphilic self-assembling peptide comprising between about 7 amino acids and 32 amino acids in an effective amount and in an effective concentration to the target area to form a hydrogel barrier under physiological conditions of the target area to treat the pulmonary bulla;
- and
- removing the delivery device from the target area,
- wherein the solution comprising the amphiphilic self-assembling peptide comprises (RADA)4 (SEQ ID NO:
- 1) at a concentration of about 0.5 weight per volume (w/v) percent.
4 more elements
A method of treating a pulmonary bulla in a subject, comprising:
- introducing a delivery device to a target area of the pulmonary bulla of the subject;
- positioning an end of the delivery device in the target area in which a treatment of the pulmonary bulla is desired;
- administering, through the delivery device, a solution comprising an amphiphilic self-assembling peptide comprising between about 7 amino acids and 32 amino acids in an effective amount and in an effective concentration to the target area to form a hydrogel barrier under physiological conditions of the target area to treat the pulmonary bulla;
- removing the delivery device from the target area;
- and
- preparing the solution comprising the amphiphilic self-assembling peptide by adding the amphiphilic self-assembling peptide to a buffer comprising at least two salts and adding the buffer to the solution,
- wherein the amphiphilic self-assembling peptide is selected from the group consisting of (RADA)4 (SEQ ID NO:
- 1), (IEIK)3I (SEQ ID NO:
- 2), and (KLDL)3 (SEQ ID NO:
- 3).
7 more elements
Dependencies are inferred from the claim text.